Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 1/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24726041 | 1.00 | KCNQ3 (0.38) | KCNQ3KCNQ2ABCB11ESR1CYP1A2 | |
| SCHEMBL24427689 | 0.87 | KDM4E (0.39) | KCNQ3KCNQ2ABCB11ESR1CYP1A2 | |
| SCHEMBL31438550 | 0.83 | MAPK8 (0.46) | KCNQ3KCNQ2ABCB11ESR1CYP1A2 | |
| SCHEMBL25198296 | 0.83 | MAPK8 (0.46) | KCNQ3KCNQ2ABCB11ESR1CYP1A2 | |
| SCHEMBL15060517 | 0.82 | ATR (0.39) | SCN9ACYP17A1GAAATRKMT2A | |
| SCHEMBL19205217 | 0.82 | ATR (0.39) | SCN9ACYP17A1GAAATRKMT2A | |
| SCHEMBL38661717 | 0.81 | ATR (0.49) | CYP1A2KDM4EHPGDSCN9ACYP17A1 | |
| SCHEMBL38663529 | 0.81 | ATR (0.49) | CYP1A2KDM4EHPGDSCN9ACYP17A1 | |
| SCHEMBL24427232 | 0.80 | AKT1 (0.36) | SCN9ACYP17A1ATRLCKGSK3B | |
| SCHEMBL29862857 | 0.80 | AKT1 (0.36) | SCN9ACYP17A1ATRLCKGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230138003-A1 | DIHYDROINDOLIZINONE DERIVATIVE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2023-05-04 | — | — | US | disclosed |
| US-11566027-B2 | Dihydroindolizinone derivative | ONO PHARMACEUTICAL CO., LTD. (JP) | 2023-01-31 | — | — | US | disclosed |
| EP-3702357-B1 | DIHYDROINDOLIZINONE DERIVATIVE | ONO PHARMACEUTICAL CO (JP) | 2022-08-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230138003-A1 | DIHYDROINDOLIZINONE DERIVATIVE | TFPI, F2, TFPI2 | KCNQ3 3496/4885KCNQ2 2846/4885ABCB11 2781/4885 |
| US-11566027-B2 | Dihydroindolizinone derivative | CYP2C19, CYP4A22, CYP4A11 | KCNQ3 2842/4885KCNQ2 2063/4885ABCB11 1038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.