CYP4A22 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2753072	0.56	3/20
SCHEMBL2752346	0.52	3/20
SCHEMBL2752131	0.52	3/20
SCHEMBL1165314	0.47	3/20
SCHEMBL971260	0.42	3/20
SCHEMBL2749440	0.42	3/20
SCHEMBL2752725	0.41	3/20
SCHEMBL2091704	0.41	3/20
SCHEMBL971261	0.40	3/20
Trifluoroacetic Acid (SCHEMBL2566375)	0.90	2/20
Trifluoroacetic Acid (SCHEMBL2592428)	0.90	2/20
Trifluoroacetic Acid (SCHEMBL2570005)	0.89	2/20
SCHEMBL2584612	0.79	2/20
SCHEMBL2407878	0.74	2/20
SCHEMBL196765	0.73	2/20
SCHEMBL2580241	0.72	2/20
Trifluoroacetic Acid (SCHEMBL2592437)	0.70	2/20
SCHEMBL2582318	0.68	2/20
SCHEMBL1180429	0.67	2/20
SCHEMBL1181635	0.67	2/20

Clinical trials — most relevant to CYP4A22 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
OPTImization of the Dose of tacroliMUS by Bayesian Prediction	PHASE4	COMPLETED
Customized Choice of Oral P2Y12 Receptor Blocker	PHASE4	UNKNOWN
Olutasidenib DDI Study in Patients With IDH1 Mutation Positive Malignancies	PHASE4	RECRUITING
Effect of Vitamin D Supplementation on Exercise Adaptations in Patients on Statin Therapy	PHASE3	COMPLETED
Activity of Regorafenib in Combination With Chemotherapy in Patients With Advanced Biliary Tract Cancer	PHASE1/PHASE2	COMPLETED
FGFR4 Inhibitor EVER4010001 in Combination With PD-1 Inhibitor Pembrolizumab in Patients With Advanced Solid Tumors	PHASE1/PHASE2	UNKNOWN
Cocktail Approach for Cytochrome P450 and P-glycoprotein Activity Assessment Using Dried Blood Spot	PHASE1	COMPLETED
Diindolylmethane in Treating Patients Undergoing Surgery for Stage I or Stage II Prostate Cancer	PHASE1	COMPLETED
Effect of Dexamethasone on CYP Enzyme Activity in Healthy Male Subjects	PHASE1	NOT_YET_RECRUITING
A Study of CYP-001 for the Treatment of Steroid-Resistant Acute Graft Versus Host Disease	PHASE1	COMPLETED
Efavirenz for Patients With Alzheimer's Disease	PHASE1	COMPLETED
Safety and Pharmacology Study of SNX-5422 in Subjects With Resistant Lung Adenocarcinoma	PHASE1	COMPLETED
A Safety and Pharmacokinetics Study of RC220 Combined With Doxorubicin in Adult Participants With Solid Tumours.	PHASE1	RECRUITING
Connecting Breath and Mind for CYP With Long COVID	nan	UNKNOWN
PhaRmacOgenetics and Therapeutic Drug Monitoring In SchizophrEnia	nan	NOT_YET_RECRUITING
Mutation Analysis of 17α-Hydroxylase	nan	UNKNOWN
Prospective Cytochrome P450 Genotyping and Clinical Outcomes in Patients With Psychosis	nan	COMPLETED
Cholesterol Metabolites as Markers for CYP3A Induction	nan	COMPLETED
Polycystic Ovary Syndrome in Type 1 Diabetes	nan	NOT_YET_RECRUITING
CYP2D6 Genotyping by AmpliChipTM CYP450 for Tamoxifen-Treated Breast Cancer Patients	nan	UNKNOWN
Pharmacogenetic Dosage Algorithm for Acenocoumarol	nan	COMPLETED
Influence of a Combined Pharmacogenetic Score on Through Plasma Voriconazole Concentrations in Haematological Patients	nan	COMPLETED
Clopidogrel Preventive Effect Based on CYP2C19 Genotype in Ischemic Stroke	nan	COMPLETED
The Clinical and Economic Impact of Pharmacogenomic Testing for Tamoxifen Metabolism in Postmenopausal Women Receiving Tamoxifen for Prevention of Recurrent Breast Cancer	nan	COMPLETED
Cholesterol and CYP3A4/5 Metabolism Across Pregnancy and Postpartum	nan	COMPLETED
Effectiveness of Raltegravir-Based Antiretroviral Therapy in HIV-HCV Coinfected Liver Transplant Recipients	nan	COMPLETED
Pharmacogenomic Profiling of Pediatric Patients	nan	COMPLETED
A Prospective Observational Study of Biomarkers for a Personalised IVF Treatment	nan	UNKNOWN
CYP2D6 Screening for Adverse Drug Reactions to Codeine in Breast Milk	nan	COMPLETED
Impact of Acute and Chronic Inflammation on Cytochromes P450 Activity Measured With Dried Blood Spot	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a CYP4A22 binder may also engage these)

Protein	Name	Similarity
CYP4A11	Cytochrome P450 4A11	1.000	landscape →
Q9GJX5	—	0.994	Q9GJX5 →
P14579	—	0.992	P14579 →
P14581	—	0.991	P14581 →
P14580	—	0.990	P14580 →
P10611	—	0.989	P10611 →
Q8SPK0	—	0.989	Q8SPK0 →
Q8SPK1	—	0.984	Q8SPK1 →
O35728	—	0.978	O35728 →
CYP46A1	Cholesterol 24-hydroxylase	0.974	landscape →
O77809	—	0.973	O77809 →
Q9WVK8	—	0.972	Q9WVK8 →
P24464	—	0.969	P24464 →
Q5KQT6	—	0.968	Q5KQT6 →
CYP1A2	Cytochrome P450 1A2	0.968	landscape →
P20817	—	0.968	P20817 →
P20816	—	0.966	P20816 →
P30099	—	0.966	P30099 →
P15539	—	0.966	P15539 →
P30100	—	0.965	P30100 →
CYP4B1	Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1)	0.964	landscape →
O93299	—	0.963	O93299 →
O93297	—	0.963	O93297 →
Q4H4C3	—	0.963	Q4H4C3 →
P15150	—	0.962	P15150 →
Q64658	—	0.961	Q64658 →
P00185	—	0.961	P00185 →
O77810	—	0.961	O77810 →
Q3LFT9	—	0.961	Q3LFT9 →
A2A974	—	0.960	A2A974 →