⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL275728 | 0.67 | — | — | |
| SCHEMBL22549094 | 0.64 | MAPK1 (0.31) | — | |
| SCHEMBL29577064 | 0.61 | — | — | |
| SCHEMBL502316 | 0.61 | — | — | |
| SCHEMBL6675970 | 0.59 | NOS3 (0.42) | — | |
| SCHEMBL31266597 | 0.58 | — | — | |
| SCHEMBL26601677 | 0.58 | — | — | |
| SCHEMBL8608711 | 0.58 | — | — | |
| SCHEMBL8351556 | 0.58 | — | — | |
| SCHEMBL24425440 | 0.58 | SLC6A3 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024032615-A1 | CRYSTAL FORM OF PYRIDINOPYRIMIDINONE COMPOUND, ACID SALT THEREOF, CRYSTAL FORM OF ACID SALT THEREOF, AND USE | 武汉人福创新药物研发中心有限公司 | 2024-02-15 | — | — | WO | disclosed |
| CN-117534667-A | Crystal forms of pyridopyrimidinone compound, acid salts thereof, crystal forms of acid salts thereof and use | 武汉人福创新药物研发中心有限公司 | 2024-02-09 | — | — | CN | disclosed |
| WO-2024008185-A1 | PHARMACEUTICAL COMPOSITION CONTAINING SOS1 INHIBITOR | 武汉人福创新药物研发中心有限公司 | 2024-01-11 | — | — | WO | disclosed |
| CN-117357650-A | Pharmaceutical composition comprising SOS1 inhibitor | 武汉人福创新药物研发中心有限公司 | 2024-01-09 | — | — | CN | disclosed |
| CN-114907341-A | Pyridopyrimidinone derivatives, and preparation method and application thereof | 武汉人福创新药物研发中心有限公司 | 2022-08-16 | — | — | CN | disclosed |
| WO-2022166974-A1 | PYRIDOPYRIMIDINONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-08-11 | — | — | WO | disclosed |