⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1499314 | 0.98 | CA2 (0.36) | — | |
| Succinic Acid SCHEMBL29701135 | 0.91 | TSHR (0.35) | — | |
| Pyrimidine SCHEMBL27849976 | 0.88 | F7 (0.33) | — | |
| SCHEMBL1321921 | 0.81 | — | — | |
| SCHEMBL2561694 | 0.80 | CAPN1 (0.46) | — | |
| Hydrochloric Acid SCHEMBL25267909 | 0.79 | ALDH1A1 (0.37) | — | |
| SCHEMBL3073583 | 0.79 | — | — | |
| SCHEMBL10514948 | 0.79 | — | — | |
| SCHEMBL1259011 | 0.79 | — | — | |
| SCHEMBL24690840 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3480193-B1 | PYRAZOLE DERIVATIVES AS ALK5 INHIBITORS AND USES THEREOF | HANMI PHARMACEUTICAL CO LTD (KR) | 2024-05-29 | — | — | EP | claimed |
| WO-2022114164-A1 | HETEROARYL CARBOXAMIDE COMPOUND | アステラス製薬株式会社 | 2022-06-02 | — | — | WO | claimed |
| CN-111699180-B | Pyrazole N-linked carbamoyl cyclohexyl acid as LPA antagonist | 百时美施贵宝公司 | 2024-11-29 | — | — | CN | disclosed |
| CN-112262140-B | Pesticidally active heterocyclic derivatives with sulfoximine containing substituents | 先正达农作物保护股份公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-110753691-B | Compounds for therapeutic and/or prophylactic treatment of cancer | 豪夫迈·罗氏有限公司 | 2024-02-02 | — | — | CN | disclosed |
| WO-2023164537-A1 | PYRAZOLYL COMPOUNDS AS KV7 CHANNEL ACTIVATORS | BIOHAVEN THERAPEUTICS LTD. (US) | 2023-08-31 | — | — | WO | disclosed |
| WO-2023164536-A1 | PYRAZOLYL COMPOUNDS AS KV7 CHANNEL ACTIVATORS | BIOHAVEN THERAPEUTICS LTD. (US) | 2023-08-31 | — | — | WO | disclosed |
| WO-2023164538-A1 | PYRAZOLYL COMPOUNDS AS KV7 CHANNEL ACTIVATORS | BIOHAVEN THERAPEUTICS LTD. (US) | 2023-08-31 | — | — | WO | disclosed |
| EP-4214197-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | Nura Bio, Inc. (US) | 2023-07-26 | — | — | EP | disclosed |
| CN-115605194-A | Treatment of excessive inflammatory syndrome | 诺莫雷蒂斯私人有限公司（BE） | 2023-01-13 | — | — | CN | disclosed |
| EP-4086255-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE IN PREVENTING OR TREATING BACTERIAL INFECTIONS | Mutabilis (FR) | 2022-11-09 | — | — | EP | disclosed |
| US-7125878-B2 | Substituted pyrroline kinase inhibitors | JANSSEN PHARMACEUTICA (BE) | 2006-10-24 | — | — | US | disclosed |
| US-20060205762-A1 | Substituted pyrroline kinase inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-09-14 | — | — | US | disclosed |
| US-20060205763-A1 | Substituted pyrroline kinase inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-09-14 | — | — | US | disclosed |
| EP-1506192-A1 | SUBSTITUTED PYRROLINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| US-20040006095-A1 | Substituted pyrroline kinase inhibitors | JANSSEN PHARMAECUTICA, NV (BE) | 2004-01-08 | — | — | US | disclosed |
| WO-2003095452-A1 | SUBSTITUTED PYRROLINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-20 | — | — | WO | disclosed |
| EP-1320531-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002012242-A2 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2002-02-14 | — | — | WO | disclosed |
| EP-0248434-A1 | Thiadiazolylacetamide derivatives, process for the preparation thereof and their use | Eisai Co., Ltd. (JP) | 1987-12-09 | — | — | EP | disclosed |