Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 4/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.43 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2987185 | 0.85 | MKNK2 (0.55) | PARP10SYKAURKBINCENPLMNA | |
| SCHEMBL28310422 | 0.83 | PARP10 (0.52) | PARP10LMNANPC1RAB9APOLB | |
| SCHEMBL14720212 | 0.80 | PLA2G2A (0.59) | PARP10POLBMKNK1CHEK2MKNK2 | |
| SCHEMBL28853596 | 0.80 | EGFR (0.52) | SYKAURKBINCENPLMNANPC1 | |
| SCHEMBL2987888 | 0.80 | CYP17A1 (0.56) | MKNK1CHEK2MKNK2CDC7GSK3B | |
| SCHEMBL4530801 | 0.78 | MKNK1 (0.46) | POLBMKNK1CHEK2MKNK2MAPT | |
| SCHEMBL30556643 | 0.77 | CHEK2 (0.44) | SYKAURKBPOLBMKNK1CHEK2 | |
| SCHEMBL28188264 | 0.77 | CHEK2 (0.44) | SYKAURKBPOLBMKNK1CHEK2 | |
| SCHEMBL1568725 | 0.77 | PARP10 (0.54) | PARP10NPC1RAB9APOLBASIC3 | |
| SCHEMBL2984193 | 0.76 | MKNK1 (0.53) | NPC1RAB9AMKNK1CHEK2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781591-B2 | Substituted 3-cyanopyridines as protein kinase inhibitors | WYETH LLC (US) | 2010-08-24 | — | — | US | disclosed |
| US-20070287708-A1 | Substituted 3-cyanopyridines as protein kinase inhibitors | WYETH LLC | 2007-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070287708-A1 | Substituted 3-cyanopyridines as protein kinase inhibitors | CNKSR1, MAP3K1, MAP3K7 | PARP10 979/4885SYK 414/4885AURKB 705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.