Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 18/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | CPB1 | P15086 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2987631 | 1.00 | CCR2 (0.55) | CCR2CYP2D6KCNH2CPB1 | |
| SCHEMBL3425020 | 0.92 | CCR2 (0.54) | CCR2CYP2D6KCNH2 | |
| SCHEMBL3425012 | 0.92 | CCR2 (0.54) | CCR2CYP2D6KCNH2 | |
| SCHEMBL3427499 | 0.90 | CCR2 (0.50) | CCR2CYP2D6KCNH2CPB1 | |
| SCHEMBL3427501 | 0.90 | CCR2 (0.50) | CCR2CYP2D6KCNH2CPB1 | |
| SCHEMBL3427504 | 0.90 | CCR2 (0.50) | CCR2CYP2D6KCNH2CPB1 | |
| SCHEMBL2989537 | 0.85 | CCR2 (0.50) | CCR2KCNH2CPB1 | |
| SCHEMBL2992417 | 0.85 | CCR2 (0.50) | CCR2KCNH2CPB1 | |
| SCHEMBL2992421 | 0.85 | CCR2 (0.50) | CCR2KCNH2CPB1 | |
| SCHEMBL2989535 | 0.85 | CCR2 (0.50) | CCR2KCNH2CPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7776884-B2 | Cyclic derivatives as modulators of chemokine receptors activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-08-17 | — | — | US | disclosed |
| US-7087604-B2 | Cyclic derivatives as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-08-08 | — | — | US | disclosed |