Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 10/20 | 0.70 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.70 |
| ▸ | TNIK | Q9UKE5 | 10/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28882904 | 0.87 | ROCK2 (0.71) | ROCK2ROCK1TNIK | |
| SCHEMBL11985664 | 0.82 | PRMT5 (0.49) | ROCK2ROCK1TNIK | |
| SCHEMBL30914658 | 0.80 | ROCK2 (0.81) | ROCK2ROCK1TNIK | |
| SCHEMBL19929676 | 0.79 | ROCK2 (0.72) | ROCK2ROCK1TNIK | |
| SCHEMBL2021305 | 0.77 | TNIK (0.56) | ROCK2ROCK1TNIK | |
| SCHEMBL28836222 | 0.76 | ROCK2 (0.65) | ROCK2ROCK1TNIK | |
| SCHEMBL29783081 | 0.76 | ROCK2 (0.65) | ROCK2ROCK1TNIK | |
| SCHEMBL31562959 | 0.74 | L3MBTL1 (0.52) | ROCK2ROCK1 | |
| SCHEMBL38653482 | 0.74 | PRMT5 (0.51) | — | |
| SCHEMBL16014355 | 0.74 | TNIK (0.58) | ROCK2ROCK1TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113773316-B | TNIK inhibitor and preparation method and application thereof | 四川大学 | 2022-10-14 | — | — | CN | disclosed |