Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23153936 | 1.00 | TDP1 (0.50) | TDP1CYP3A4ALOX15SMN1; SMN2TP53 | |
| SCHEMBL24179051 | 0.83 | TDP1 (0.50) | TDP1CYP3A4ALOX15SMN1; SMN2TP53 | |
| SCHEMBL17607326 | 0.81 | ALOX15 (0.48) | TDP1CYP3A4ALOX15SMN1; SMN2TP53 | |
| SCHEMBL29633722 | 0.81 | ALOX15 (0.48) | TDP1CYP3A4ALOX15SMN1; SMN2TP53 | |
| SCHEMBL24073372 | 0.78 | HPGD (0.33) | TDP1CYP3A4ALOX15SMN1; SMN2TP53 | |
| SCHEMBL28659364 | 0.78 | CYP3A4 (0.45) | TDP1CYP3A4ALOX15SMN1; SMN2TP53 | |
| SCHEMBL4403108 | 0.77 | HPGD (0.41) | TDP1CYP3A4TP53ALDH1A1TSHR | |
| SCHEMBL24781081 | 0.77 | — | — | |
| SCHEMBL18812816 | 0.77 | ALDH1A1 (0.46) | ALDH1A1CA1L3MBTL1HTT | |
| SCHEMBL20092385 | 0.77 | CA14 (0.39) | TDP1CYP3A4ALOX15SMN1; SMN2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022194269-A1 | NOVEL EGFR DEGRADATION AGENT | 上海齐鲁制药研究中心有限公司 | 2022-09-22 | — | — | WO | disclosed |