Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NNMT | P40261 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1769713 | 1.00 | KMT2A (0.38) | KMT2AKDM4EALDH1A1MEN1HSD17B10 | |
| SCHEMBL10233308 | 0.86 | KMT2A (0.38) | KMT2AKDM4EALDH1A1MEN1HSD17B10 | |
| SCHEMBL14401106 | 0.86 | KMT2A (0.40) | KMT2AKDM4EALDH1A1MEN1HSD17B10 | |
| SCHEMBL13889991 | 0.84 | KMT2A (0.38) | KMT2AKDM4EALDH1A1MEN1HSD17B10 | |
| SCHEMBL28849076 | 0.83 | GAA (0.45) | ALDH1A1HSD17B10GAAMAPTHPGD | |
| SCHEMBL10906291 | 0.80 | KDM4E (0.53) | KMT2AKDM4EALDH1A1MEN1HSD17B10 | |
| SCHEMBL10256197 | 0.78 | MEN1 (0.41) | KMT2AKDM4EALDH1A1MEN1HSD17B10 | |
| SCHEMBL22462285 | 0.77 | KDM4E (0.43) | KMT2AKDM4EALDH1A1MEN1HSD17B10 | |
| SCHEMBL29803501 | 0.77 | KDM4E (0.43) | KMT2AKDM4EALDH1A1MEN1HSD17B10 | |
| SCHEMBL3250596 | 0.77 | ALOX15 (0.43) | KMT2AKDM4EALDH1A1MEN1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114940683-B | HPK1 inhibitors and uses thereof | 轩竹(北京)医药科技有限公司 | 2023-01-17 | — | — | CN | disclosed |
| CN-114940683-A | HPK1 inhibitors and uses thereof | 轩竹(北京)医药科技有限公司 | 2022-08-26 | — | — | CN | disclosed |