Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1321069 | 0.91 | ALOX15 (0.44) | ALOX15ALDH1A1POLBTDP1HPGD | |
| SCHEMBL27888762 | 0.87 | BRD4 (0.38) | ALDH1A1TDP1HPGDCYP1A2HSD17B10 | |
| SCHEMBL5567814 | 0.86 | ALDH1A1 (0.44) | ALDH1A1HPGDSMN1; SMN2TP53CYP1A2 | |
| SCHEMBL1760643 | 0.86 | ALDH1A1 (0.44) | ALDH1A1HPGDSMN1; SMN2TP53CYP1A2 | |
| SCHEMBL7286562 | 0.86 | ALDH1A1 (0.44) | ALDH1A1HPGDSMN1; SMN2TP53CYP1A2 | |
| SCHEMBL862579 | 0.86 | BRD4 (0.42) | ALDH1A1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL27792278 | 0.85 | PKM (0.46) | ALDH1A1POLBHPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL10256197 | 0.85 | MEN1 (0.41) | ALDH1A1POLBHPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL10909269 | 0.84 | GAA (0.40) | ALDH1A1POLBTDP1HPGDCYP1A2 | |
| SCHEMBL11956678 | 0.83 | TNF (0.41) | ALDH1A1POLBHPGDSMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1330454-B1 | BENZOPYRANYL HETEROCYCLE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DONGBU HITEK CO LTD (KR) | 2010-05-19 | — | — | EP | disclosed |
| US-20090192147-A1 | [a]-FUSED INDOLE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH (US) | 2009-07-30 | — | — | US | disclosed |
| EP-1330454-A4 | BENZOPYRANYL HETEROCYCLE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DONGBU HANNONG CHEMICAL CO LTD (KR) | 2008-03-19 | — | — | EP | disclosed |
| EP-1330454-A1 | BENZOPYRANYL HETEROCYCLE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dongbu Hannong Chemical Co., Ltd. (KR) | 2003-07-30 | — | — | EP | disclosed |
| US-6413983-B1 | COUPLING EPOXIDE WITH INDOLE OR QUINOLINE COMPOUND; PROTECT-ING HEART, BRAIN, RETINA AND NEURONAL CELL FROM ?ISCHEMIA-REPERFUSION? INJURY; SUPPRESSING LIPID PEROXIDATION | DONGBU HANNONG CHEMICAL CO. LTD. (KR) | 2002-07-02 | — | — | US | disclosed |
| WO-2002030925-A1 | BENZOPYRANYL HETEROCYCLE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DONGBU HANNONG CHEMICAL CO., LTD (KR) | 2002-04-18 | — | — | WO | disclosed |
| EP-0024852-B1 | 2,3-DIHYDRO-1H-INDOLE DERIVATIVES AND INTERMEDIATES THEREFOR, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE DERIVATIVES AND THEIR PREPARATION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1986-09-03 | — | — | EP | disclosed |
| US-4599357-A | 1-mercaptoalkanoylindoline-2-carboxylic acids | CIBA-GEIGY CORPORATION (US) | 1986-07-08 | — | — | US | disclosed |
| US-4454292-A | CHEMICAL INTERMEDIATES OF ANGIOTENSIN CONVERTING ENZYNE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-06-12 | — | — | US | disclosed |
| US-4454291-A | HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-06-12 | — | — | US | disclosed |
| US-4396773-A | 1,1'-[Dithiobis(2-alkyl-1-oxo-3,1-propanediyl)]-bis[2,3-dihydro-1H-indole-2-carboxylic acids and derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1983-08-02 | — | — | US | disclosed |
| US-4385180-A | 10,10a-Dihydro-1H-thiozino[4,3-a,]-indole-1,4(3H)-diones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1983-05-24 | — | — | US | disclosed |
| US-4350633-A | ENZYME INHIBITORS, HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-09-21 | — | — | US | disclosed |
| US-4303583-A | 1H,5H-[1,4]Thiazepino[4,3-a]indole-1,5-diones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-12-01 | — | — | US | disclosed |
| EP-0024852-A1 | 2,3-Dihydro-1H-indole derivatives and intermediates therefor, processes for their preparation, pharmaceutical compositions containing these derivatives and their preparation | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-03-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192147-A1 | [a]-FUSED INDOLE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | MTOR, RICTOR, PIK3C2A | ALOX15 4231/4885ALDH1A1 3904/4885POLB 4521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.