Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.42 |
| ▸ | RPS6KA2 | Q15349 | 6/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 4/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 2/20 | 0.38 |
| ▸ | CCND1 | P24385 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29879213 | 0.80 | HRH3 (0.45) | HRH3RPS6KA2RPS6KA3MAPKAPK2CYP2D6 | |
| SCHEMBL30104808 | 0.76 | RPS6KA2 (0.42) | HRH3RPS6KA2RPS6KA3MAPKAPK2CYP2D6 | |
| SCHEMBL29153647 | 0.76 | HRH3 (0.49) | HRH3RPS6KA2RPS6KA3MAPKAPK2CYP2D6 | |
| SCHEMBL30104848 | 0.76 | HRH3 (0.49) | HRH3RPS6KA2RPS6KA3MAPKAPK2CYP2D6 | |
| SCHEMBL24640536 | 0.74 | CDK4 (0.42) | HRH3RPS6KA2RPS6KA3MAPKAPK2CYP2D6 | |
| SCHEMBL30104854 | 0.73 | HTR2C (0.49) | — | |
| SCHEMBL30967663 | 0.71 | RPS6KA3 (0.52) | HRH3RPS6KA2RPS6KA3MAPKAPK2CYP2D6 | |
| SCHEMBL19187485 | 0.71 | HRH3 (0.52) | HRH3RPS6KA2RPS6KA3MAPKAPK2CYP2D6 | |
| SCHEMBL22570165 | 0.70 | CDK4 (0.50) | HRH3RPS6KA2RPS6KA3MAPKAPK2CYP2D6 | |
| SCHEMBL24187442 | 0.69 | RPS6KA3 (0.42) | HRH3RPS6KA2RPS6KA3MAPKAPK2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117396485-A | PARP7 inhibitors | 轩竹生物科技股份有限公司 | 2024-01-12 | — | — | CN | disclosed |
| WO-2022247839-A1 | PARP7 INHIBITOR | 山东轩竹医药科技有限公司 | 2022-12-01 | — | — | WO | disclosed |