Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24737990 | 1.00 | HRH4 (0.34) | HRH4 | |
| SCHEMBL29879251 | 0.88 | HRH4 (0.32) | HRH4 | |
| SCHEMBL24737991 | 0.88 | HRH4 (0.32) | HRH4 | |
| SCHEMBL24737988 | 0.86 | HDAC3 (0.33) | HRH4 | |
| SCHEMBL24737671 | 0.84 | — | — | |
| SCHEMBL29136929 | 0.78 | METTL3 (0.41) | — | |
| SCHEMBL30997769 | 0.78 | HRH1 (0.38) | HRH4 | |
| SCHEMBL24738259 | 0.78 | HRH1 (0.38) | HRH4 | |
| SCHEMBL29879323 | 0.78 | MAP4K1 (0.33) | — | |
| SCHEMBL24737878 | 0.76 | DRD2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308230-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197758-A1 | HETEROARYL INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |