Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.55 |
| ▸ | PRKCQ | Q04759 | 8/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | KHK | P50053 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2797038 | 0.81 | LMNA (0.60) | KITPDE10AJAK3LMNAHTT | |
| SCHEMBL2797263 | 0.80 | HTR2C (0.55) | HTT | |
| SCHEMBL2743003 | 0.76 | TRPV1 (0.46) | KITPRKCQPRKCDMAPK13MAPK12 | |
| SCHEMBL4425614 | 0.76 | TRPV1 (0.46) | KITPRKCQPRKCDMAPK13MAPK12 | |
| SCHEMBL6281370 | 0.76 | HTR2C (0.65) | KITPRKCQPRKCDKHKADRA2A | |
| SCHEMBL6271843 | 0.76 | HTR2C (0.65) | KITPRKCQPRKCDKHKADRA2A | |
| SCHEMBL2421374 | 0.75 | PRKCQ (0.45) | KITPRKCQPRKCDMAPK13MAPK12 | |
| SCHEMBL232058 | 0.75 | TRPV1 (0.47) | KITPRKCQPRKCDMAPK13MAPK12 | |
| SCHEMBL3707817 | 0.75 | TRPV1 (0.47) | KITPRKCQPRKCDMAPK13MAPK12 | |
| SCHEMBL2425193 | 0.75 | PRKCQ (0.45) | KITPRKCQPRKCDMAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115135650-A | Pyridopyrimidine derivatives as KRAS inhibitors | 贝达医药公司 | 2022-09-30 | — | — | CN | disclosed |