Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.75 |
| ▸ | FADS1 | O60427 | 6/20 | 0.69 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | IDO1 | P14902 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ALPL | P05186 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TTK | P33981 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.50 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4741513 | 1.00 | TRPA1 (0.75) | TRPA1FADS1GRM4ADRA2AAURKA | |
| SCHEMBL7346388 | 0.87 | TRPA1 (0.69) | TRPA1FADS1GRM4ADRA2AAURKA | |
| SCHEMBL27604456 | 0.86 | TRPA1 (0.71) | TRPA1FADS1GRM4ADRA2AHPGD | |
| SCHEMBL4822088 | 0.86 | TRPA1 (0.71) | TRPA1FADS1GRM4ADRA2AAURKA | |
| SCHEMBL29592533 | 0.86 | TRPA1 (0.71) | TRPA1FADS1GRM4ADRA2AEGFR | |
| SCHEMBL4785847 | 0.82 | FADS1 (1.00) | TRPA1FADS1GRM4ADRA2AEGFR | |
| SCHEMBL4783454 | 0.82 | FADS1 (1.00) | TRPA1FADS1GRM4KDM4EEGFR | |
| SCHEMBL801419 | 0.82 | FADS1 (0.69) | TRPA1FADS1GRM4ADRA2AEGFR | |
| SCHEMBL2206804 | 0.82 | NPY5R (0.68) | TRPA1FADS1AURKAKDM4E | |
| SCHEMBL18410601 | 0.81 | TRPA1 (0.53) | TRPA1FADS1GRM4AURKAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11452717-B2 | Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof | Sanford Burnham Prebys Medical Discovery Institute (US) | 2022-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11452717-B2 | Small molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and uses thereof | NAMPT, NAPRT, NNT | TRPA1 3949/4885FADS1 175/4885GRM4 4633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.