Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 10/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2493495 | 0.88 | HRH4 (0.53) | HRH4CHEK1 | |
| SCHEMBL3003939 | 0.87 | HRH4 (0.53) | HRH4CHEK1HTR3AHRH3 | |
| SCHEMBL2515068 | 0.85 | RAB9A (0.52) | HRH4CHEK1 | |
| SCHEMBL2997040 | 0.82 | HRH4 (0.63) | HRH4HTR3AHRH3 | |
| SCHEMBL2514957 | 0.78 | HRH4 (0.53) | HRH4HTR3AHRH3 | |
| SCHEMBL14922693 | 0.75 | HRH4 (0.58) | HRH4HTR3AHRH3 | |
| SCHEMBL3001496 | 0.75 | HRH4 (0.58) | HRH4HTR3AHRH3 | |
| SCHEMBL2519482 | 0.74 | HRH4 (0.67) | HRH4HTR3AHRH3 | |
| SCHEMBL2513586 | 0.74 | HRH4 (0.67) | HRH4HTR3AHRH3 | |
| SCHEMBL2546419 | 0.73 | HRH4 (0.40) | HRH4HTR3AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130244999-A1 | Substituted Heterocyclic Compounds | INCYTE CORPORATION (US) | 2013-09-19 | — | — | US | disclosed |
| US-8436008-B2 | Substituted heterocyclic compounds | INCYTE CORPORATION (US) | 2013-05-07 | — | — | US | disclosed |
| US-20100173901-A1 | Substituted Heterocyclic Compounds | INCYTE CORPORATION (US) | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173901-A1 | Substituted Heterocyclic Compounds | HRH4, HRH2, HRH1 | HRH4 1/4885CHEK1 3167/4885HTR3A 170/4885 |
| US-20130244999-A1 | Substituted Heterocyclic Compounds | HRH4, HRH2, HRH1 | HRH4 1/4885CHEK1 3167/4885HTR3A 170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.