Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 14/20 | 0.44 |
| ▸ | JAK1 | P23458 | 13/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | BMX | P51813 | 2/20 | 0.40 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29232078 | 1.00 | TYK2 (0.44) | TYK2JAK1KCNH2MAP4K1IRAK4 | |
| SCHEMBL29232026 | 0.86 | TYK2 (0.57) | TYK2JAK1KCNH2STAT3 | |
| SCHEMBL29882710 | 0.86 | TYK2 (0.57) | TYK2JAK1KCNH2STAT3 | |
| SCHEMBL29232107 | 0.79 | AXL (0.51) | TYK2JAK1KCNH2 | |
| SCHEMBL29882777 | 0.78 | TYK2 (0.48) | TYK2JAK1KCNH2STAT3PKMYT1 | |
| SCHEMBL29883118 | 0.78 | JAK1 (0.45) | TYK2JAK1KCNH2LRRK2STAT3 | |
| SCHEMBL29232093 | 0.78 | JAK1 (0.45) | TYK2JAK1KCNH2LRRK2STAT3 | |
| SCHEMBL29232010 | 0.77 | TYK2 (0.41) | TYK2JAK1KCNH2PKMYT1PTK2 | |
| SCHEMBL29882997 | 0.76 | TYK2 (0.43) | TYK2JAK1KCNH2STAT3 | |
| SCHEMBL18357335 | 0.73 | AURKA (0.56) | KCNH2BMXPKMYT1PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115197196-B | TYK2 inhibitor and application thereof | 扬子江药业集团有限公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-115197196-A | TYK2 inhibitor and application thereof | 扬子江药业集团有限公司 | 2022-10-18 | — | — | CN | disclosed |