Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 14/20 | 0.45 |
| ▸ | TYK2 | P29597 | 12/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | ULK1 | O75385 | 1/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29232093 | 1.00 | JAK1 (0.45) | JAK1TYK2KCNH2STAT3AXL | |
| SCHEMBL29232107 | 0.82 | AXL (0.51) | JAK1TYK2KCNH2AXLMERTK | |
| SCHEMBL29232010 | 0.82 | TYK2 (0.41) | JAK1TYK2KCNH2AXLMERTK | |
| SCHEMBL31711644 | 0.80 | TYK2 (0.49) | JAK1TYK2KCNH2STAT3JAK2 | |
| SCHEMBL27417732 | 0.80 | TYK2 (0.49) | JAK1TYK2KCNH2STAT3JAK2 | |
| SCHEMBL31711632 | 0.79 | TYK2 (0.49) | JAK1TYK2KCNH2STAT3JAK2 | |
| SCHEMBL27414932 | 0.79 | TYK2 (0.49) | JAK1TYK2KCNH2STAT3JAK2 | |
| SCHEMBL29882997 | 0.79 | TYK2 (0.43) | JAK1TYK2KCNH2STAT3 | |
| SCHEMBL29232078 | 0.78 | TYK2 (0.44) | JAK1TYK2KCNH2STAT3LRRK2 | |
| SCHEMBL29882805 | 0.78 | TYK2 (0.44) | JAK1TYK2KCNH2STAT3LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115197196-B | TYK2 inhibitor and application thereof | 扬子江药业集团有限公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-115197196-A | TYK2 inhibitor and application thereof | 扬子江药业集团有限公司 | 2022-10-18 | — | — | CN | disclosed |