Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.68 |
| ▸ | RAB9A | P51151 | 7/20 | 0.65 |
| ▸ | NPC1 | O15118 | 4/20 | 0.65 |
| ▸ | TSHR | P16473 | 3/20 | 0.65 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | GLA | P06280 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2188598 | 1.00 | TDP1 (0.71) | TDP1L3MBTL1RAB9ANPC1TSHR | |
| Hydrochloric Acid SCHEMBL1503943 | 0.98 | TDP1 (0.69) | TDP1L3MBTL1RAB9ANPC1TSHR | |
| SCHEMBL2944497 | 0.86 | TDP1 (0.71) | TDP1L3MBTL1RAB9ANPC1TSHR | |
| SCHEMBL27886037 | 0.84 | TDP1 (0.73) | TDP1L3MBTL1RAB9ANPC1TSHR | |
| SCHEMBL19090370 | 0.84 | TDP1 (0.73) | TDP1L3MBTL1RAB9ANPC1TSHR | |
| SCHEMBL18286136 | 0.84 | TDP1 (0.73) | TDP1L3MBTL1RAB9ANPC1TSHR | |
| SCHEMBL222437 | 0.84 | TDP1 (0.69) | TDP1L3MBTL1RAB9ANPC1TSHR | |
| SCHEMBL11034892 | 0.84 | TDP1 (0.69) | TDP1L3MBTL1RAB9ANPC1TSHR | |
| SCHEMBL23933096 | 0.83 | TDP1 (1.00) | TDP1L3MBTL1RAB9ANPC1TSHR | |
| SCHEMBL2952697 | 0.81 | TSHR (0.69) | TDP1L3MBTL1RAB9ANPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4045142-A1 | OXAZOLE AND THIOAZOLE-TYPE CULLIN RING UBIQUITIN LIGASE COMPOUNDS AND USES THEREOF | CeMM - Forschungszentrum für Molekulare Medizin GmbH (AT) | 2022-08-24 | — | — | EP | disclosed |