Sugi Predict

Sugi Predict / Compounds / SCHEMBL2188598

SCHEMBL2188598

SCHEMBL2188598

O=C(CCl)Nc1ccc(Cl)cn1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 1/20 0.71
▸ L3MBTL1 Q9Y468 3/20 0.68
▸ RAB9A P51151 7/20 0.65
▸ NPC1 O15118 4/20 0.65
▸ TSHR P16473 3/20 0.65
▸ PTK2 Q05397 1/20 0.64
▸ MAPK1 P28482 2/20 0.63
▸ GLA P06280 1/20 0.63
▸ LMNA P02545 3/20 0.61
▸ HTT P42858 1/20 0.61
▸ NPSR1 Q6W5P4 1/20 0.61
▸ SMN1; SMN2 Q16637 3/20 0.58
▸ TP53 P04637 2/20 0.58
▸ MAPT P10636 2/20 0.58
▸ NFKB1 P19838 1/20 0.58
▸ NFKB2 Q00653 1/20 0.58
▸ RELA Q04206 1/20 0.58
▸ PKM P14618 1/20 0.58
▸ HPGD P15428 1/20 0.58
▸ ALDH1A1 P00352 2/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29883158 1.00 TDP1 (0.71) TDP1L3MBTL1RAB9ANPC1TSHR
Hydrochloric Acid SCHEMBL1503943 0.98 TDP1 (0.69) TDP1L3MBTL1RAB9ANPC1TSHR
SCHEMBL2944497 0.86 TDP1 (0.71) TDP1L3MBTL1RAB9ANPC1TSHR
SCHEMBL27886037 0.84 TDP1 (0.73) TDP1L3MBTL1RAB9ANPC1TSHR
SCHEMBL19090370 0.84 TDP1 (0.73) TDP1L3MBTL1RAB9ANPC1TSHR
SCHEMBL18286136 0.84 TDP1 (0.73) TDP1L3MBTL1RAB9ANPC1TSHR
SCHEMBL222437 0.84 TDP1 (0.69) TDP1L3MBTL1RAB9ANPC1TSHR
SCHEMBL11034892 0.84 TDP1 (0.69) TDP1L3MBTL1RAB9ANPC1TSHR
SCHEMBL23933096 0.83 TDP1 (1.00) TDP1L3MBTL1RAB9ANPC1TSHR
SCHEMBL2952697 0.81 TSHR (0.69) TDP1L3MBTL1RAB9ANPC1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12410152-B2 Oxazole and thioazole-type cullin ring ubiquitin ligase compounds and uses thereof PROXYGEN GMBH (AT) 2025-09-09 — — US disclosed
US-20230124700-A1 OXAZOLE AND THIOAZOLE-TYPE CULLIN RING UBIQUITIN LIGASE COMPOUNDS AND USES THEREOF CEMM - FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GMBH (AT) 2023-04-20 — — US disclosed
US-20230124700-A1 OXAZOLE AND THIOAZOLE-TYPE CULLIN RING UBIQUITIN LIGASE COMPOUNDS AND USES THEREOF CEMM - FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GMBH (AT) 2023-04-20 — — US disclosed
WO-2021074414-A1 OXAZOLE AND THIOAZOLE-TYPE CULLIN RING UBIQUITIN LIGASE COMPOUNDS AND USES THEREOF CEMM - FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GMBH (AT) 2021-04-22 — — WO disclosed
WO-2021074414-A1 OXAZOLE AND THIOAZOLE-TYPE CULLIN RING UBIQUITIN LIGASE COMPOUNDS AND USES THEREOF CEMM - FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GMBH (AT) 2021-04-22 — — WO disclosed
US-10758522-B2 Small molecule analogs of the nemo binding peptide THE SCRIPPS RESEARCH INSTITUTE (US) 2020-09-01 — — US disclosed
US-20180169078-A1 Small Molecule Analogs of the Nemo Binding Peptide UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED 2018-06-21 — — US disclosed
EP-3302468-A1 SMALL MOLECULE ANALOGS OF THE NEMO BINDING PEPTIDE The Scripps Research Institute (US) 2018-04-11 — — EP disclosed
WO-2016196117-A1 SMALL MOLECULE ANALOGS OF THE NEMO BINDING PEPTIDE THE SCRIPPS RESEARCH INSTITUTE (US) 2016-12-08 — — WO disclosed
EP-1405852-B9 DIAMINE DERIVATIVES DAIICHI SANKYO CO LTD (JP) 2013-03-27 — — EP disclosed
CN-1826333-A Diamine derivatives DAIICHI SEIYAKU CO (JP) 2006-08-30 — — CN disclosed
EP-1666478-A1 CARBAMOYL-TYPE BENZOFURAN DERIVATIVES TANABE SEIYAKU CO., LTD. (JP) 2006-06-07 — — EP disclosed
US-20060094724-A1 Fused furan compound MITSUBISHI TANABE PHARMA CORPORATION (JP) 2006-05-04 — — US disclosed
CN-1751025-A Diamine derivatives DAIICHI SEIYAKU CO (JP) 2006-03-22 — — CN disclosed
CN-1745071-A Novel ethylenediamine derivative DAIICHI SEIYAKU CO (JP) 2006-03-08 — — CN disclosed
CN-1723210-A Fused furan compound TANABE SEIYAKU CO (JP) 2006-01-18 — — CN disclosed
US-20050282808-A1 Benzofuran derivative MITSUBISHI TANABE PHARMA CORPORATION (JP) 2005-12-22 — — US disclosed
EP-1582521-A1 FUSED FURAN COMPOUND TANABE SEIYAKU CO., LTD. (JP) 2005-10-05 — — EP disclosed
CN-1656086-A Benzofuran derivative TANABE SEIYAKU CO (JP) 2005-08-17 — — CN disclosed
EP-1489078-A1 BENZOFURAN DERIVATIVE Tanabe Seiyaku Co., Ltd. (JP) 2004-12-22 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12410152-B2 Oxazole and thioazole-type cullin ring ubiquitin ligase compounds and uses thereof CUL1, CUL5, CUL3 TDP1 2668/4885L3MBTL1 2638/4885RAB9A 4502/4885
US-20230124700-A1 OXAZOLE AND THIOAZOLE-TYPE CULLIN RING UBIQUITIN LIGASE COMPOUNDS AND USES THEREOF CUL1, CUL5, CUL3 TDP1 2668/4885L3MBTL1 2638/4885RAB9A 4502/4885
US-20050282808-A1 Benzofuran derivative F12, F2, F11 TDP1 3656/4885L3MBTL1 4087/4885RAB9A 4616/4885
US-10758522-B2 Small molecule analogs of the nemo binding peptide IKBKG, NFKBIA, NFKB1 TDP1 745/4885L3MBTL1 1248/4885RAB9A 3026/4885
US-20060094724-A1 Fused furan compound F2, F12, F11 TDP1 4423/4885L3MBTL1 3595/4885RAB9A 4494/4885
US-20180169078-A1 Small Molecule Analogs of the Nemo Binding Peptide IKBKG, NFKBIA, NFKB1 TDP1 745/4885L3MBTL1 1248/4885RAB9A 3026/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.