Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.51 |
| ▸ | STAT1 | P42224 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.33 |
| ▸ | TERT | O14746 | 2/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL584374 | 1.00 | STAT3 (0.51) | STAT3STAT1PPARGPPARAHDAC3 | |
| SCHEMBL584793 | 0.99 | STAT3 (0.52) | STAT3STAT1PPARGPPARAHDAC3 | |
| SCHEMBL14383960 | 0.93 | STAT3 (0.46) | STAT3STAT1PPARGPPARACHEK2 | |
| Exeporfinium SCHEMBL584418 | 0.89 | STAT3 (0.51) | STAT3STAT1TERTCYP1A2CYP19A1 | |
| Hydrochloric Acid SCHEMBL588717 | 0.88 | STAT3 (0.41) | STAT3STAT1PPARGPPARATERT | |
| SCHEMBL12066656 | 0.88 | STAT3 (0.48) | STAT3STAT1PPARGPPARATERT | |
| Exeporfinium SCHEMBL585997 | 0.88 | STAT3 (0.52) | STAT3STAT1TERT | |
| SCHEMBL585139 | 0.87 | STAT3 (0.41) | STAT3STAT1PPARGPPARADHFR | |
| Exeporfinium SCHEMBL5012396 | 0.87 | STAT3 (0.51) | STAT3STAT1TERT | |
| Hydrochloric Acid SCHEMBL29648896 | 0.87 | STAT3 (0.48) | STAT3STAT1TERTCYP1A2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022180380-A1 | COMBINATION OF MUPIROCIN WITH PORPHYRIN-BASED PHOTOSENSITIZERS FOR REDUCING ANTIBIOTIC RESISTANCE EMERGENCE | DESTINY PHARMA PLC (GB) | 2022-09-01 | — | — | WO | claimed |
| WO-2022180380-A1 | COMBINATION OF MUPIROCIN WITH PORPHYRIN-BASED PHOTOSENSITIZERS FOR REDUCING ANTIBIOTIC RESISTANCE EMERGENCE | DESTINY PHARMA PLC (GB) | 2022-09-01 | — | — | WO | disclosed |