Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.43 |
| ▸ | GABRD | O14764 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.43 |
| ▸ | GABRE | P78334 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23693567 | 1.00 | HSD11B1 (0.47) | HSD11B1TSHRHSD17B10ALDH1A1CYP3A4 | |
| SCHEMBL5927386 | 0.86 | KCNMA1 (0.46) | HSD11B1TSHRHSD17B10KCNMA1KDM4E | |
| SCHEMBL28716910 | 0.86 | GRM2 (0.46) | HSD11B1TSHRHSD17B10ALDH1A1CYP3A4 | |
| SCHEMBL22737967 | 0.85 | HSD17B10 (0.50) | TSHRHSD17B10ALDH1A1CYP3A4TDP1 | |
| SCHEMBL31067088 | 0.85 | HSD11B1 (0.51) | HSD11B1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL20898069 | 0.85 | HSD11B1 (0.51) | HSD11B1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL21638114 | 0.85 | TSHR (0.42) | HSD11B1TSHRHSD17B10ALDH1A1CYP3A4 | |
| SCHEMBL31186822 | 0.85 | TSHR (0.42) | HSD11B1TSHRHSD17B10ALDH1A1CYP3A4 | |
| SCHEMBL30184931 | 0.84 | GRM2 (0.45) | HSD11B1ALDH1A1KCNMA1KDM4EGABRP | |
| SCHEMBL20898552 | 0.83 | HSD11B1 (0.49) | HSD11B1GABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114981251-B | Dibenzofuran derivative cathepsin K inhibitor and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-114981251-A | Diphenyl furan derivative cathepsin K inhibitor and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2022-08-30 | — | — | CN | disclosed |