Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 3/20 | 0.58 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.48 |
| ▸ | TTR | P02766 | 4/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23673496 | 1.00 | MMP12 (0.58) | MMP12MTHFD2CHEK1TTRPTGER4 | |
| SCHEMBL29886896 | 0.78 | CHRNA7 (0.54) | MMP12NPC1RAB9ASMN1; SMN2HSP90AA1 | |
| SCHEMBL11768568 | 0.78 | TTR (0.65) | TTRPTGER4NPC1RAB9ATP53 | |
| SCHEMBL29887322 | 0.76 | HTR3A (0.53) | MMP12NPC1RAB9AKDM4E | |
| SCHEMBL23693776 | 0.76 | MMP12 (0.47) | MMP12NPC1RAB9ATP53LMNA | |
| SCHEMBL17737081 | 0.76 | HTR3A (0.61) | CHEK1NPC1RAB9ATP53LMNA | |
| SCHEMBL63450 | 0.74 | CHEK1 (0.70) | CHEK1NPC1RAB9ATP53LMNA | |
| SCHEMBL30175920 | 0.74 | TTR (0.68) | TTRPTGER4TP53LMNASMN1; SMN2 | |
| SCHEMBL69226 | 0.74 | TTR (0.68) | TTRPTGER4TP53LMNASMN1; SMN2 | |
| SCHEMBL4014142 | 0.74 | MMP12 (1.00) | MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114981251-B | Dibenzofuran derivative cathepsin K inhibitor and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-114981251-A | Diphenyl furan derivative cathepsin K inhibitor and preparation method and medical application thereof | 深圳信立泰药业股份有限公司 | 2022-08-30 | — | — | CN | disclosed |