Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.64 |
| ▸ | HTR3B | O95264 | 4/20 | 0.64 |
| ▸ | HTR3A | P46098 | 4/20 | 0.64 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.64 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.64 |
| ▸ | HTR2C | P28335 | 3/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.64 |
| ▸ | HTR1A | P08908 | 2/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | HTR7 | P34969 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | HTR6 | P50406 | 1/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9058023 | 0.86 | HTR3E (0.62) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL24394801 | 0.85 | NPC1 (0.45) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL3550058 | 0.83 | NPC1 (0.44) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Quipazine SCHEMBL322181 | 0.78 | KDM4E (1.00) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Quipazine SCHEMBL4062074 | 0.77 | KDM4E (0.97) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL23744763 | 0.74 | PDE10A (0.47) | PRKD1 | |
| SCHEMBL30345709 | 0.74 | PDE10A (0.47) | PRKD1 | |
| SCHEMBL5746441 | 0.73 | HTR3A (0.62) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL5912936 | 0.73 | HTR3A (0.62) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL15724675 | 0.73 | HTR3A (0.62) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4322945-A2 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022221528-A2 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-10-20 | — | — | WO | disclosed |