Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | EED | O75530 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.40 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.36 |
| ▸ | SLC6A11 | P48066 | 2/20 | 0.36 |
| ▸ | SLC6A13 | Q9NSD5 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22265774 | 1.00 | HRH4 (0.44) | HRH4HRH3GBA1SLC6A4SLC6A2 | |
| SCHEMBL16138420 | 0.89 | GBA1 (0.55) | HRH4HRH3GBA1SLC6A4SLC6A2 | |
| Hydrochloric Acid SCHEMBL16112905 | 0.87 | GBA1 (0.53) | HRH4HRH3GBA1SLC6A4SLC6A2 | |
| SCHEMBL21006152 | 0.84 | CACNA1G (0.36) | GBA1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL1812734 | 0.83 | EED (0.52) | HRH3GBA1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL21608008 | 0.83 | HRH3 (0.50) | HRH4HRH3GBA1SLC6A4EED | |
| SCHEMBL13740423 | 0.83 | EED (0.52) | HRH3GBA1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL13739140 | 0.83 | EED (0.52) | HRH3GBA1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL21603165 | 0.82 | HRH3 (0.45) | HRH4HRH3GBA1SLC6A4SLC6A2 | |
| SCHEMBL1811296 | 0.81 | GBA1 (0.52) | HRH4HRH3GBA1SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12336991-B2 | Factor XIIA inhibitors | UNIVERSITY OF LEEDS (GB) | 2025-06-24 | — | — | US | disclosed |
| US-20220305011-A1 | FACTOR XIIA INHIBITORS | UNIVERSITY OF LEEDS (GB) | 2022-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220305011-A1 | FACTOR XIIA INHIBITORS | F11, F13B, F12 | HRH4 1531/4885HRH3 1500/4885GBA1 536/4885 |
| US-12336991-B2 | Factor XIIA inhibitors | F11, F13B, F12 | HRH4 1531/4885HRH3 1500/4885GBA1 536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.