Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18713909 | 0.81 | USP2 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL15274776 | 0.81 | USP2 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23891777 | 0.80 | AKR1C3 (0.41) | — | |
| SCHEMBL531071 | 0.77 | APP (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL19493737 | 0.75 | CES2 (0.34) | — | |
| SCHEMBL30271733 | 0.74 | TRPV4 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4430697 | 0.74 | TRPV4 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL15274780 | 0.74 | SLC6A4 (0.33) | APPSLC6A4SLC6A2SLC6A3CYP1A2 | |
| SCHEMBL16956706 | 0.73 | APP (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23011826 | 0.73 | APP (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012025182-A1 | SWITCH ELEMENT COMPRISING A LIQUID-CRYSTALLINE MEDIUM | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | disclosed |