Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 4/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23249822 | 1.00 | CYP11B2 (0.43) | CYP11B2CYP11B1CYP17A1CYP3A4CHRNB4 | |
| SCHEMBL23263139 | 0.81 | HDAC4 (0.53) | CYP11B2CYP11B1CYP17A1CYP3A4CHRNB4 | |
| SCHEMBL29890214 | 0.80 | PARP10 (0.43) | CYP11B2CYP11B1CYP17A1CYP3A4CHRNB4 | |
| SCHEMBL29890183 | 0.80 | PARP10 (0.43) | CYP11B2CYP11B1CYP17A1CYP3A4PARP10 | |
| SCHEMBL23249804 | 0.80 | PARP10 (0.43) | CYP11B2CYP11B1CYP17A1CYP3A4PARP10 | |
| SCHEMBL23249855 | 0.80 | PARP10 (0.43) | CYP11B2CYP11B1CYP17A1CYP3A4CHRNB4 | |
| SCHEMBL23263315 | 0.79 | CYP11B2 (0.40) | CYP11B2CYP11B1CYP17A1CYP3A4CHRNB4 | |
| SCHEMBL29891580 | 0.77 | RNASEH1 (0.42) | CYP11B2CYP11B1CYP17A1CYP3A4PARP10 | |
| SCHEMBL23249826 | 0.77 | RNASEH1 (0.42) | CYP11B2CYP11B1CYP17A1CYP3A4PARP10 | |
| SCHEMBL23249843 | 0.76 | CYP3A4 (0.41) | CYP11B2CYP11B1CYP17A1CYP3A4PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4045025-A1 | TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS | Ambys Medicines, Inc. (US) | 2022-08-24 | — | — | EP | disclosed |