Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 11/20 | 0.83 |
| ▸ | NFE2L2 | Q16236 | 8/20 | 0.83 |
| ▸ | SQSTM1 | Q13501 | 2/20 | 0.83 |
| ▸ | MITF | O75030 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.71 |
| ▸ | GAA | P10253 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | THRB | P10828 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.71 |
| ▸ | CASP1 | P29466 | 1/20 | 0.71 |
| ▸ | GFER | P55789 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.71 |
| ▸ | CKS1B | P61024 | 3/20 | 0.69 |
| ▸ | SKP2 | Q13309 | 3/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29892935 | 0.96 | KEAP1 (0.81) | KEAP1NFE2L2SQSTM1MITFALDH1A1 | |
| SCHEMBL28841713 | 0.94 | STAT3 (0.76) | KEAP1NFE2L2SQSTM1MITFALDH1A1 | |
| SCHEMBL26089402 | 0.91 | KEAP1 (1.00) | KEAP1NFE2L2SQSTM1MITFALDH1A1 | |
| SCHEMBL28347360 | 0.91 | STAT3 (0.77) | KEAP1NFE2L2SQSTM1MITFALDH1A1 | |
| SCHEMBL29892528 | 0.85 | KEAP1 (0.77) | KEAP1NFE2L2SQSTM1MITFALDH1A1 | |
| SCHEMBL29540814 | 0.85 | KEAP1 (0.68) | KEAP1NFE2L2SQSTM1MITFALDH1A1 | |
| SCHEMBL22234983 | 0.85 | KEAP1 (0.68) | KEAP1NFE2L2SQSTM1MITFALDH1A1 | |
| SCHEMBL29028543 | 0.84 | KEAP1 (0.86) | KEAP1NFE2L2SQSTM1MITFALDH1A1 | |
| SCHEMBL23443367 | 0.83 | KEAP1 (1.00) | KEAP1NFE2L2SQSTM1MITFALDH1A1 | |
| SCHEMBL21511039 | 0.83 | GAA (1.00) | KEAP1NFE2L2SQSTM1MITFALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110698367-B | N- (1-substituted naphthyl) -4-methoxybenzenesulphonamide compound and preparation and application thereof | 温州医科大学 | 2022-08-19 | — | — | CN | disclosed |