Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 16/20 | 1.00 |
| ▸ | NFE2L2 | Q16236 | 10/20 | 1.00 |
| ▸ | SQSTM1 | Q13501 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 0.83 |
| ▸ | MITF | O75030 | 1/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.83 |
| ▸ | LMNA | P02545 | 1/20 | 0.83 |
| ▸ | TP53 | P04637 | 1/20 | 0.83 |
| ▸ | MAPT | P10636 | 1/20 | 0.83 |
| ▸ | THRB | P10828 | 1/20 | 0.83 |
| ▸ | HPGD | P15428 | 1/20 | 0.83 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.83 |
| ▸ | CASP1 | P29466 | 1/20 | 0.83 |
| ▸ | GFER | P55789 | 1/20 | 0.83 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.83 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.83 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.83 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29028543 | 0.93 | KEAP1 (0.86) | KEAP1NFE2L2SQSTM1GAAMITF | |
| SCHEMBL29892350 | 0.91 | KEAP1 (0.83) | KEAP1NFE2L2SQSTM1GAAMITF | |
| SCHEMBL23443367 | 0.91 | KEAP1 (1.00) | KEAP1NFE2L2SQSTM1GAAMITF | |
| SCHEMBL28347367 | 0.91 | KEAP1 (0.83) | KEAP1NFE2L2SQSTM1GAAMITF | |
| SCHEMBL21511039 | 0.91 | GAA (1.00) | KEAP1NFE2L2SQSTM1GAAMITF | |
| SCHEMBL29892935 | 0.90 | KEAP1 (0.81) | KEAP1NFE2L2SQSTM1GAAMITF | |
| SCHEMBL28841731 | 0.89 | KEAP1 (0.79) | KEAP1NFE2L2SQSTM1GAAMITF | |
| SCHEMBL12768028 | 0.88 | KEAP1 (0.81) | KEAP1NFE2L2SQSTM1GAAMITF | |
| SCHEMBL38662927 | 0.88 | KEAP1 (0.77) | KEAP1NFE2L2SQSTM1GAAMITF | |
| SCHEMBL29892528 | 0.88 | KEAP1 (0.77) | KEAP1NFE2L2SQSTM1GAAMITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230127304-A1 | NEW INHIBITORS FOR THE KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230127304-A1 | NEW INHIBITORS FOR THE KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION | KEAP1, HMOX1, NFE2L2 | KEAP1 1/4885NFE2L2 3/4885SQSTM1 172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.