Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.56 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.56 |
| ▸ | GRIA3 | P42263 | 3/20 | 0.56 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.56 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.56 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.56 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.56 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.56 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.56 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MPI | P34949 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9037104 | 0.81 | GRIA1 (0.62) | POLBGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL29893296 | 0.79 | PARP1 (0.56) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL19036232 | 0.79 | HRH4 (0.54) | HRH4HRH3ALDH1A1 | |
| SCHEMBL9037382 | 0.76 | GRIA1 (0.50) | GRIA1GRIA2GRIA3GRIA4PARP1 | |
| SCHEMBL9038799 | 0.75 | GRIA1 (0.68) | POLBGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL30273081 | 0.74 | POLB (1.00) | POLBGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL29893237 | 0.74 | TP53 (0.61) | GRIA1GRIA2GRIA3GRIA4PARP1 | |
| SCHEMBL7353512 | 0.74 | GRIA1 (0.50) | GRIA1GRIA2GRIA3GRIA4PARP1 | |
| SCHEMBL9037767 | 0.72 | GRIA1 (1.00) | POLBGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL23576679 | 0.71 | PARP1 (0.46) | GRIA1GRIA2GRIA3GRIA4PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0518530-B1 | Improvements in or relating to excitatory amino acid receptor antagonists | LILLY CO ELI (US) | 1996-10-09 | — | — | EP | disclosed |
| US-5196421-A | Treatment of neurological disorders | ELI LILLY AND COMPANY (US) | 1993-03-23 | — | — | US | disclosed |
| EP-0518530-A2 | Improvements in or relating to excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1992-12-16 | — | — | EP | disclosed |
| US-5153196-A | Administering for reduction of neurotransmission in nervous system disorders | ELI LILLY AND COMPANY (US) | 1992-10-06 | — | — | US | disclosed |