Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.44 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.44 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | PPARD | Q03181 | 3/20 | 0.43 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSPO | P30536 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | ACP1 | P24666 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29892985 | 0.84 | KDM4E (0.49) | MAPK1MAP2K4MAPK6MAPKAPK5KDM4E | |
| SCHEMBL29893305 | 0.83 | P2RY14 (0.48) | MAPK1MAP2K4MAPK6MAPKAPK5KDM4E | |
| SCHEMBL27077506 | 0.83 | HDAC4 (0.48) | KDM4EADORA3RAB9A | |
| SCHEMBL29893059 | 0.81 | NAMPT (0.51) | PPARD | |
| SCHEMBL29893009 | 0.81 | P2RY14 (0.57) | MAPK1MAP2K4MAPK6MAPKAPK5P2RY14 | |
| SCHEMBL29893763 | 0.81 | ESR1 (0.50) | MAPK1MAP2K4MAPK6MAPKAPK5KDM4E | |
| SCHEMBL29893198 | 0.80 | P2RY14 (0.47) | MAPK1MAP2K4MAPK6MAPKAPK5P2RY14 | |
| SCHEMBL29892662 | 0.80 | ACP1 (0.49) | MAPK1MAP2K4MAPK6MAPKAPK5P2RY14 | |
| SCHEMBL29893057 | 0.80 | P2RY14 (0.44) | MAPK1MAP2K4MAPK6MAPKAPK5P2RY14 | |
| SCHEMBL29893360 | 0.79 | ADORA3 (0.44) | KDM4EADORA3ACP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313308-A1 | TEAD INHIBITORS AND USES THEREOF | Cedilla Therapeutics, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022204452-A1 | TEAD INHIBITORS AND USES THEREOF | CEDILLA THERAPEUTICS, INC. (US) | 2022-09-29 | — | — | WO | disclosed |