Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SUV39H2 | Q9H5I1 | 5/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.36 |
| ▸ | FPR1 | P21462 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23299990 | 1.00 | GAA (0.41) | GAASUV39H2AKT1MAPTCYP1A2 | |
| SCHEMBL23275378 | 1.00 | GAA (0.41) | GAASUV39H2AKT1MAPTCYP1A2 | |
| SCHEMBL23275320 | 0.84 | MAPT (0.40) | AKT1MAPTCYP1A2CYP2D6RAF1 | |
| SCHEMBL23275324 | 0.84 | MAPT (0.40) | AKT1MAPTCYP1A2CYP2D6RAF1 | |
| SCHEMBL29900790 | 0.83 | JAK3 (0.40) | GAASUV39H2AKT1MAPTCYP1A2 | |
| SCHEMBL23275253 | 0.83 | JAK3 (0.40) | GAASUV39H2AKT1MAPTCYP1A2 | |
| SCHEMBL23299989 | 0.83 | JAK3 (0.40) | GAASUV39H2AKT1MAPTCYP1A2 | |
| SCHEMBL28830319 | 0.79 | CYP1A2 (0.39) | GAAAKT1MAPTCYP1A2CYP2D6 | |
| SCHEMBL28830320 | 0.78 | SLC6A3 (0.35) | SUV39H2 | |
| SCHEMBL23274606 | 0.75 | RAF1 (0.46) | AKT1MAPTCYP1A2CYP2D6RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4048259-A1 | INHIBITORS OF RAF KINASES | Kinnate Biopharma Inc. (US) | 2022-08-31 | — | — | EP | disclosed |
| CN-114845711-A | Inhibitors of RAF kinase | 金耐特生物制药公司 | 2022-08-02 | — | — | CN | disclosed |