Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 2/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.37 |
| ▸ | SELE | P16581 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 2/20 | 0.37 |
| ▸ | MERTK | Q12866 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30159190 | 0.83 | CREBBP (0.40) | CREBBPICAM1SELEMEN1KMT2A | |
| SCHEMBL14725093 | 0.81 | CREBBP (0.40) | CREBBPICAM1SELEAXLMERTK | |
| SCHEMBL1732484 | 0.81 | ALDH1A1 (0.46) | ICAM1SELEMEN1KMT2ANPC1 | |
| SCHEMBL18355699 | 0.79 | TACR1 (0.46) | CREBBPMEN1KMT2AKDM4CEP300 | |
| SCHEMBL1732627 | 0.79 | KDM4C (0.41) | CREBBPICAM1SELEMEN1KMT2A | |
| SCHEMBL29901049 | 0.79 | MEN1 (0.36) | CREBBPICAM1SELEAXLMERTK | |
| SCHEMBL23647767 | 0.77 | ICAM1 (0.39) | CREBBPICAM1SELEMEN1KMT2A | |
| SCHEMBL1704863 | 0.77 | L3MBTL1 (0.41) | CREBBPICAM1SELEAXLMERTK | |
| SCHEMBL3078260 | 0.76 | ICAM1 (0.40) | CREBBPICAM1SELEAXLMERTK | |
| SCHEMBL16727109 | 0.76 | ICAM1 (0.38) | CREBBPICAM1SELEMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4110776-A1 | NEW MACROCYCLIC COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Les Laboratoires Servier (FR) | 2023-01-04 | — | — | EP | disclosed |
| CN-115151538-A | Macrocyclic compounds, process for their preparation and pharmaceutical compositions containing them | 法国施维雅药厂 | 2022-10-04 | — | — | CN | disclosed |