Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | SALL4 | Q9UJQ4 | 2/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PKLR | P30613 | 1/20 | 0.42 |
| ▸ | TRIM33 | Q9UPN9 | 3/20 | 0.42 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2989801 | 0.92 | GAA (0.59) | GAAMAPTNR1H4SMN1; SMN2KDM4E | |
| SCHEMBL2986384 | 0.90 | MAPT (0.57) | GAAMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2988779 | 0.83 | GAA (0.56) | GAAMAPTNR1H4SMN1; SMN2KDM4E | |
| SCHEMBL2992236 | 0.81 | GAA (0.63) | GAAMAPTNR1H4SMN1; SMN2KDM4E | |
| SCHEMBL2989961 | 0.80 | GAA (0.67) | GAAMAPTNR1H4SMN1; SMN2KDM4E | |
| SCHEMBL2993469 | 0.80 | GAA (0.67) | GAAMAPTNR1H4SMN1; SMN2KDM4E | |
| SCHEMBL2992275 | 0.80 | GAA (0.61) | GAAMAPTNR1H4SMN1; SMN2KDM4E | |
| SCHEMBL2989981 | 0.78 | GAA (0.64) | GAAMAPTNR1H4SMN1; SMN2KDM4E | |
| SCHEMBL2988133 | 0.78 | MAPT (0.64) | GAAMAPTNR1H4SMN1; SMN2KDM4E | |
| SCHEMBL2989983 | 0.78 | GAA (0.64) | GAAMAPTNR1H4SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173930-A1 | Certain Chemical Entities, Compositions and Methods | CYTOKINETICS, INC. | 2010-07-08 | — | — | US | claimed |
| WO-2008016648-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-02-07 | — | — | WO | claimed |
| US-20100173930-A1 | Certain Chemical Entities, Compositions and Methods | CYTOKINETICS, INC. | 2010-07-08 | — | — | US | disclosed |
| WO-2008016648-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173930-A1 | Certain Chemical Entities, Compositions and Methods | TNNC1, TNNI3, TNNT2 | GAA 820/4885MAPT 218/4885NR1H4 4747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.