Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 12/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 12/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 9/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23771192 | 0.80 | TSHR (0.50) | CHRNB2CHRNA4CHRNB4CHRNA3MEN1 | |
| Bromide SCHEMBL17746919 | 0.78 | TSHR (0.48) | CHRNB2CHRNA4CHRNB4CHRNA3MEN1 | |
| SCHEMBL3682553 | 0.78 | TSHR (0.63) | MEN1KMT2ATSHR | |
| SCHEMBL7763388 | 0.75 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL4060095 | 0.75 | TSHR (0.67) | MEN1KMT2ATSHR | |
| SCHEMBL10262406 | 0.72 | TSHR (0.55) | MEN1KMT2ATSHR | |
| SCHEMBL30997594 | 0.71 | KMT2A (0.52) | CHRNB2CHRNA4MEN1KMT2ATSHR | |
| SCHEMBL30997592 | 0.71 | KMT2A (0.52) | CHRNB2CHRNA4MEN1KMT2ATSHR | |
| SCHEMBL19091086 | 0.70 | TSHR (0.45) | MEN1KMT2ATSHR | |
| SCHEMBL17908775 | 0.70 | TSHR (0.50) | MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4076492-A1 | PCSK9 ANTAGONIST COMPOUNDS | Merck Sharp & Dohme LLC (US) | 2022-10-26 | — | — | EP | disclosed |