Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.62 |
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
| ▸ | AMY1A | P0DUB6 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29903330 | 0.86 | SMN1; SMN2 (0.65) | RAB9AMAPTSMN1; SMN2NPC1POLB | |
| SCHEMBL30808829 | 0.83 | MEN1 (0.55) | RAB9AMAPTSMN1; SMN2NPC1MEN1 | |
| SCHEMBL29903394 | 0.82 | MAPT (0.61) | RAB9AMAPTSMN1; SMN2NPC1POLB | |
| SCHEMBL3469929 | 0.81 | KMT2A (0.59) | RAB9AMAPTSMN1; SMN2NPC1POLB | |
| SCHEMBL30808836 | 0.80 | KMT2A (0.67) | RAB9AMAPTSMN1; SMN2NPC1POLB | |
| SCHEMBL29722093 | 0.76 | RAB9A (0.69) | RAB9AMAPTSMN1; SMN2NPC1POLB | |
| SCHEMBL29903328 | 0.75 | CYP2D6 (0.60) | MAPTNPC1POLBMEN1LMNA | |
| SCHEMBL3011508 | 0.74 | MAOB (0.58) | MAPTPOLBMEN1LMNAKMT2A | |
| SCHEMBL3011502 | 0.74 | MAOB (0.58) | MAPTPOLBMEN1LMNAKMT2A | |
| N'-(4-Nitrobenzylidene)Isonicotinohydrazide SCHEMBL2984424 | 0.74 | MAPT (0.73) | RAB9AMAPTSMN1; SMN2NPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115043824-A | Compound with SIRT6 deacetylation inhibiting activity, SIRT6 inhibitor and application thereof | 上海交通大学医学院 | 2022-09-13 | — | — | CN | disclosed |