Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.66 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.56 |
| ▸ | INSR | P06213 | 2/20 | 0.56 |
| ▸ | IGF1R | P08069 | 2/20 | 0.56 |
| ▸ | ROS1 | P08922 | 5/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26906651 | 1.00 | EGFR (0.66) | EGFRALKINSRIGF1RROS1 | |
| SCHEMBL26906871 | 0.87 | EGFR (0.50) | EGFRALKINSRIGF1RROS1 | |
| SCHEMBL30659734 | 0.87 | ALK (0.62) | EGFRALKINSRIGF1RROS1 | |
| SCHEMBL29904636 | 0.86 | EGFR (0.58) | EGFRALKROS1 | |
| SCHEMBL29114865 | 0.86 | EGFR (0.63) | EGFRALKINSRIGF1RROS1 | |
| SCHEMBL29904689 | 0.86 | EGFR (0.63) | EGFRALKINSRIGF1RROS1 | |
| SCHEMBL26906900 | 0.85 | EGFR (0.59) | EGFRALKROS1 | |
| SCHEMBL26906870 | 0.85 | EGFR (0.60) | EGFRALKINSRIGF1RROS1 | |
| SCHEMBL22462120 | 0.80 | ALK (0.76) | EGFRALKINSRIGF1RROS1 | |
| SCHEMBL22821899 | 0.79 | EGFR (1.00) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022211573-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2022-10-06 | — | — | WO | claimed |
| WO-2022211573-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2022-10-06 | — | — | WO | disclosed |