Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 13/20 | 0.49 |
| ▸ | INSR | P06213 | 2/20 | 0.49 |
| ▸ | IGF1R | P08069 | 2/20 | 0.49 |
| ▸ | ROS1 | P08922 | 6/20 | 0.47 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26906651 | 0.87 | EGFR (0.66) | EGFRALKINSRIGF1RROS1 | |
| SCHEMBL29904679 | 0.87 | EGFR (0.66) | EGFRALKINSRIGF1RROS1 | |
| SCHEMBL30659720 | 0.85 | ALK (0.53) | EGFRALKINSRROS1 | |
| SCHEMBL28530455 | 0.79 | EGFR (0.79) | EGFRALKINSRIGF1R | |
| SCHEMBL28536447 | 0.78 | EGFR (0.69) | EGFR | |
| SCHEMBL29904717 | 0.77 | ALK (0.46) | EGFRALKINSRIGF1RROS1 | |
| SCHEMBL26906810 | 0.77 | ZAP70 (0.66) | EGFRALKINSRIGF1RROS1 | |
| SCHEMBL29904620 | 0.77 | ZAP70 (0.66) | EGFRALKINSRIGF1RROS1 | |
| SCHEMBL28908537 | 0.77 | EGFR (0.81) | EGFR | |
| SCHEMBL22595142 | 0.77 | EGFR (0.61) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4286376-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | Therapex Co., Ltd. (KR) | 2023-12-06 | — | — | EP | disclosed |