Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 7/20 | 0.60 |
| ▸ | INSR | P06213 | 6/20 | 0.60 |
| ▸ | IGF1R | P08069 | 4/20 | 0.60 |
| ▸ | MET | P08581 | 2/20 | 0.59 |
| ▸ | EGFR | P00533 | 11/20 | 0.58 |
| ▸ | AXL | P30530 | 3/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.58 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.58 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.58 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.58 |
| ▸ | NEK2 | P51955 | 2/20 | 0.58 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | STK25 | O00506 | 1/20 | 0.58 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.58 |
| ▸ | CASK | O14936 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.58 |
| ▸ | GAK | O14976 | 1/20 | 0.58 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26906730 | 1.00 | ALK (0.60) | ALKINSRIGF1RMETEGFR | |
| SCHEMBL29904622 | 0.88 | EGFR (0.70) | ALKINSRIGF1REGFRROS1 | |
| SCHEMBL29114866 | 0.88 | EGFR (0.70) | ALKINSRIGF1REGFRROS1 | |
| SCHEMBL26906797 | 0.87 | ALK (0.68) | ALKINSRIGF1RMETEGFR | |
| SCHEMBL29904658 | 0.85 | CDK9 (0.59) | ALKINSRIGF1RMETEGFR | |
| SCHEMBL26906721 | 0.85 | CDK9 (0.59) | ALKINSRIGF1RMETEGFR | |
| SCHEMBL26906661 | 0.83 | ALK (0.87) | ALKINSRIGF1RMETEGFR | |
| SCHEMBL12781751 | 0.81 | ALK (0.85) | ALKINSRIGF1RMETEGFR | |
| SCHEMBL12781316 | 0.81 | ALK (0.77) | ALKINSRIGF1RMETEGFR | |
| SCHEMBL26906628 | 0.81 | ALK (0.75) | ALKINSRIGF1RMETEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022211573-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2022-10-06 | — | — | WO | claimed |
| WO-2022211573-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2022-10-06 | — | — | WO | disclosed |