Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 4/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
| ▸ | AXL | P30530 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | STK17B | O94768 | 1/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.36 |
| ▸ | S100A9 | P06702 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30833643 | 0.83 | ALK (0.43) | ALKINSRMAPK9MAPK10 | |
| SCHEMBL30833659 | 0.76 | AURKA (0.48) | ALKJAK2 | |
| SCHEMBL30659905 | 0.76 | MAPK3 (0.45) | ALKMAPK3AXLEGFR | |
| SCHEMBL29114898 | 0.76 | MAPK3 (0.45) | ALKMAPK3AXLEGFR | |
| SCHEMBL1203504 | 0.75 | MAPK10 (0.57) | ALKINSRMAPK3NTRK1MAPK9 | |
| SCHEMBL2061640 | 0.74 | AXL (0.44) | ALKINSRMAPK3AXLEGFR | |
| SCHEMBL20085639 | 0.74 | ALK (0.58) | ALKINSREGFR | |
| SCHEMBL12813270 | 0.73 | AXL (0.62) | ALKINSRAXL | |
| SCHEMBL1203926 | 0.72 | MAPK10 (0.57) | ALKINSRMAPK3NTRK1MAPK9 | |
| SCHEMBL17411151 | 0.72 | ALK (0.51) | ALKINSRMAPK3EGFRPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022211573-A1 | PYRIMIDINE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME | 주식회사 테라펙스 | 2022-10-06 | — | — | WO | disclosed |