Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | DHODH | Q02127 | 2/20 | 0.55 |
| ▸ | BRD3 | Q15059 | 7/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | CDC42 | P60953 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4022197 | 1.00 | CYP2D6 (0.61) | CYP2D6KCNH2DHODHBRD3MAPT | |
| SCHEMBL21114855 | 1.00 | CYP2D6 (0.61) | CYP2D6KCNH2DHODHBRD3MAPT | |
| SCHEMBL4021701 | 0.89 | CYP2D6 (0.60) | CYP2D6KCNH2DHODHBRD3MAPT | |
| SCHEMBL4024942 | 0.89 | CYP2D6 (0.60) | CYP2D6KCNH2DHODHBRD3MAPT | |
| SCHEMBL4024328 | 0.88 | CYP2D6 (0.57) | CYP2D6KCNH2DHODHBRD3MAPT | |
| SCHEMBL13780962 | 0.88 | DHODH (0.71) | DHODHBRD3MAPTALOX15SMN1; SMN2 | |
| SCHEMBL4021888 | 0.86 | CYP2D6 (0.67) | CYP2D6KCNH2DHODHBRD3MAPT | |
| SCHEMBL4024141 | 0.86 | CYP2D6 (0.67) | CYP2D6KCNH2DHODHBRD3MAPT | |
| SCHEMBL4025938 | 0.86 | CYP2D6 (0.67) | CYP2D6KCNH2DHODHBRD3MAPT | |
| SCHEMBL4025623 | 0.85 | CYP2D6 (0.56) | CYP2D6KCNH2DHODHBRD3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240325373-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE IN COMBINATION WITH AN ANTI-CD47-SIRPA THERAPEUTIC AGENT | OHIO STATE INNOVATION FOUNDATION (US) | 2024-10-03 | — | — | US | disclosed |
| EP-4362968-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE IN COMBINATION WITH AN ANTI-CD47-SIRPA THERAPEUTIC AGENT | Ohio State Innovation Foundation (US) | 2024-05-08 | — | — | EP | disclosed |
| CN-117915938-A | Methods and compositions for inhibiting dihydroorotate dehydrogenase in combination with anti-CD 47-sirpa therapeutic agents | 俄亥俄州国家创新基金会 | 2024-04-19 | — | — | CN | disclosed |
| US-20230303710-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE IN COMBINATION WITH AN ANTI-CD38 THERAPEUTIC AGENT | OHIO STATE INNOVATION FOUNDATION (US) | 2023-09-28 | — | — | US | disclosed |
| WO-2023043830-A1 | COMBINATION THERAPIES TO TREAT VIRAL INFECTIONS | Clear Creek Bio, Inc. (US) | 2023-03-23 | — | — | WO | disclosed |
| WO-2023278778-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE IN COMBINATION WITH AN ANTI-CD47-SIRPΑ THERAPEUTIC AGENT | OHIO STATE INNOVATION FOUNDATION (US) | 2023-01-05 | — | — | WO | disclosed |
| CN-115335052-A | Methods and compositions for inhibiting dihydroorotate dehydrogenase in combination with anti-CD 38 therapeutics | 俄亥俄州国家创新基金会 | 2022-11-11 | — | — | CN | disclosed |
| EP-4081219-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE IN COMBINATION WITH AN ANTI-CD38 THERAPEUTIC AGENT | Ohio State Innovation Foundation (US) | 2022-11-02 | — | — | EP | disclosed |
| US-20220280513-A1 | ENHANCING THE ANTIVIRAL EFFICACY OF RNA VIRUS INHIBITION BY COMBINATION WITH MODULATORS OF PYRIMIDINE METABOLISM | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2022-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240325373-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE IN COMBINATION WITH AN ANTI-CD47-SIRPA THERAPEUTIC AGENT | DHODH, CD47, IDH1 | CYP2D6 1031/4885KCNH2 1886/4885DHODH 1/4885 |
| US-20230303710-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE IN COMBINATION WITH AN ANTI-CD38 THERAPEUTIC AGENT | DHODH, CD38, DPYD | CYP2D6 414/4885KCNH2 1619/4885DHODH 1/4885 |
| US-20220280513-A1 | ENHANCING THE ANTIVIRAL EFFICACY OF RNA VIRUS INHIBITION BY COMBINATION WITH MODULATORS OF PYRIMIDINE METABOLISM | EIF2AK2, RNGTT, RNMT | CYP2D6 1448/4885KCNH2 4197/4885DHODH 167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.