Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 3/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.44 |
| ▸ | NPBWR1 | P48145 | 7/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.38 |
| ▸ | BUB1 | O43683 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23210876 | 1.00 | GRIN1 (0.44) | GRIN1GRIN2BNPBWR1DCTPP1BUB1 | |
| SCHEMBL23210971 | 0.94 | GRIN1 (0.46) | GRIN1GRIN2BNPBWR1DCTPP1BUB1 | |
| SCHEMBL30308773 | 0.94 | GRIN1 (0.46) | GRIN1GRIN2BNPBWR1DCTPP1BUB1 | |
| SCHEMBL29907069 | 0.75 | BUB1 (0.39) | DCTPP1BUB1OPRK1KDM4EALDH1A1 | |
| SCHEMBL23210986 | 0.75 | BUB1 (0.39) | DCTPP1BUB1OPRK1KDM4EALDH1A1 | |
| SCHEMBL23210919 | 0.75 | GRIN1 (0.49) | GRIN1GRIN2BNPBWR1DCTPP1MCHR1 | |
| SCHEMBL30308758 | 0.75 | GRIN1 (0.49) | GRIN1GRIN2BNPBWR1DCTPP1MCHR1 | |
| SCHEMBL23211078 | 0.74 | BUB1 (0.35) | DCTPP1BUB1OPRK1KDM4EALDH1A1 | |
| SCHEMBL23210908 | 0.72 | ROCK2 (0.41) | BUB1 | |
| SCHEMBL29907185 | 0.72 | ROCK2 (0.41) | BUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4045151-A1 | BICYCLIC HETEROCYCLES AS FGFR INHIBITORS | Incyte Corporation (US) | 2022-08-24 | — | — | EP | disclosed |