Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | CBFB | Q13951 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12894974 | 1.00 | DRD2 (0.54) | DRD2DRD4DRD3CBFBBRD4 | |
| SCHEMBL31588180 | 0.98 | DRD2 (0.52) | DRD2DRD4DRD3CBFBBRD4 | |
| SCHEMBL11784065 | 0.86 | DRD2 (0.58) | DRD2DRD4DRD3BRD4HTR1A | |
| SCHEMBL10140 | 0.81 | BRD4 (0.60) | DRD2DRD4DRD3CBFBBRD4 | |
| SCHEMBL8130854 | 0.79 | DRD4 (0.58) | DRD2DRD4DRD3BRD4HTR1A | |
| SCHEMBL8486072 | 0.79 | DRD4 (0.58) | DRD2DRD4DRD3BRD4HTR1A | |
| SCHEMBL4604974 | 0.79 | PARP1 (0.46) | DRD2DRD4DRD3BRD4PARP1 | |
| SCHEMBL9529342 | 0.78 | DRD4 (0.64) | DRD2DRD4DRD3BRD4HTR1A | |
| SCHEMBL7280669 | 0.78 | DRD4 (0.57) | DRD2DRD4DRD3BRD4HTR1A | |
| SCHEMBL7280664 | 0.78 | DRD4 (0.44) | DRD2DRD4DRD3BRD4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4326719-A1 | PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE | Université de Montréal (CA) | 2024-02-28 | — | — | EP | disclosed |
| WO-2022221939-A1 | PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE | UNIVERSITE DE MONTREAL (CA) | 2022-10-27 | — | — | WO | disclosed |