Sugi Predict

Sugi Predict / Compounds / SCHEMBL10140

SCHEMBL10140

SCHEMBL10140

COc1cccc2[nH]cnc12

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BRD4 O60885 1/20 0.60
▸ ABL1 P00519 1/20 0.54
▸ RAD52 P43351 1/20 0.54
▸ RIN1 Q13671 1/20 0.54
▸ RET P07949 1/20 0.49
▸ DRD2 P14416 1/20 0.49
▸ DRD4 P21917 1/20 0.49
▸ DRD3 P35462 1/20 0.49
▸ HTR2A P28223 1/20 0.46
▸ HTR2C P28335 1/20 0.46
▸ PARP1 P09874 1/20 0.46
▸ KEAP1 Q14145 1/20 0.46
▸ NFE2L2 Q16236 1/20 0.46
▸ HPGD P15428 2/20 0.45
▸ ALDH1A1 P00352 1/20 0.45
▸ TP53 P04637 1/20 0.45
▸ CYP3A4 P08684 1/20 0.45
▸ CYP2D6 P10635 1/20 0.45
▸ ALOX15 P16050 1/20 0.45
▸ CYP2C19 P33261 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nitric Acid SCHEMBL14695919 0.87 BRD4 (0.50) BRD4ABL1RAD52RIN1RET
Nitric Acid SCHEMBL14695921 0.87 BRD4 (0.50) BRD4ABL1RAD52RIN1RET
SCHEMBL29907232 0.81 DRD2 (0.54) BRD4ABL1RAD52RIN1DRD2
SCHEMBL12894974 0.81 DRD2 (0.54) BRD4ABL1RAD52RIN1DRD2
SCHEMBL23123499 0.80 DRD2 (0.46) BRD4ABL1RAD52RIN1RET
SCHEMBL31588180 0.80 DRD2 (0.52) BRD4ABL1RAD52RIN1DRD2
SCHEMBL11784065 0.79 DRD2 (0.58) BRD4RETDRD2DRD4DRD3
SCHEMBL7430992 0.79 PARP1 (0.49) BRD4ABL1RAD52RIN1RET
SCHEMBL15724303 0.78 PARP1 (0.47) BRD4ABL1RAD52RIN1RET
SCHEMBL8486068 0.78 PARP1 (0.44) BRD4ABL1RAD52RIN1RET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-5201808-A — — None — — JP disclosed
EP-4598923-A1 SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS The Regents of the University of California (US) 2025-08-13 — — EP disclosed
CN-120035595-A Thiazolo [5,4-d ] pyrimidine compounds, compositions comprising the same and uses thereof 蒙特利尔大学 2025-05-23 — — CN disclosed
US-20250041319-A1 BICYCLIC HETEROARYL DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS RIBOSCIENCE LLC 2025-02-06 — — US disclosed
US-12029744-B2 Bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors RIBOSCIENCE LLC (US) 2024-07-09 — — US disclosed
US-20240197682-A1 METHOD FOR TREATING NEUROLOGICAL DISEASES USING SUPRAMOLECULE POLYMER THERAPEUTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-06-20 — — US disclosed
US-20240201205-A1 METHOD FOR DETECTING NEUROLOGICAL DISEASES USING SUPRAMOLECULE POLYMER THERAPEUTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-06-20 — — US disclosed
US-20240199604-A1 SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-06-20 — — US disclosed
US-20240199604-A1 SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-06-20 — — US disclosed
US-20240199604-A1 SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-06-20 — — US disclosed
US-7790025-B2 External gradient chromatofocusing CRYOBIOPHYSICA, INC. (US) 2010-09-07 — — US disclosed
US-20070144973-A1 External gradient chromatofocusing CRYOBIOPHYSICA, INC. (US) 2007-06-28 — — US disclosed
EP-1628729-A2 EXTERNAL GRADIENT CHROMATOFOCUSING Cryobiophysica, Inc. (US) 2006-03-01 — — EP disclosed
WO-2004103519-A2 EXTERNAL GRADIENT CHROMATOFOCUSING CRYOBIOPHYSICA, INC. (US) 2004-12-02 — — WO disclosed
US-20030226769-A1 Kit for assaying saccharified protein SODE KOJI (JP) 2003-12-11 — — US disclosed
JP-H05201808-A NEMATOCIDAL COMPOSITION CIBA GEIGY AG 1993-08-10 — — JP disclosed
EP-0346367-A1 ARYL- AND ARYLOXY-SUBSTITUTED TERT.-ALKYLENAMINES, PROCESS FOR THEIR MANUFACTURE AND THEIR USE IN PHARMACY SCHERING AKTIENGESELLSCHAFT (DE) 1989-12-20 — — EP disclosed
WO-1988006580-A1 ARYL- AND ARYLOXY-SUBSTITUTED TERT.-ALKYLENAMINES, PROCESS FOR THEIR MANUFACTURE AND THEIR USE IN PHARMACY SCHERING AKTIENGESELLSCHAFT (DE) 1988-09-07 — — WO disclosed
US-3988155-A CYANINE SENSITIZING DYES FUJI PHOTO FILM CO., LTD. (JA) 1976-10-26 — — US disclosed
US-3985563-A Silver halide photographic emulsion FUJI PHOTO FILM CO., LTD. (JA) 1976-10-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240199604-A1 SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS MAPT, HTT, PSEN1 BRD4 269/4885ABL1 3168/4885RAD52 926/4885
US-20250041319-A1 BICYCLIC HETEROARYL DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS ENPP1, ENPP3, SMPD1 BRD4 1614/4885ABL1 928/4885RAD52 4504/4885
US-12029744-B2 Bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors ENPP1, ENPP3, SMPD1 BRD4 1627/4885ABL1 977/4885RAD52 4520/4885
US-20240197682-A1 METHOD FOR TREATING NEUROLOGICAL DISEASES USING SUPRAMOLECULE POLYMER THERAPEUTICS PRNP, PSEN1, SNCA BRD4 1840/4885ABL1 4182/4885RAD52 2581/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.