Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TDP2 | O95551 | 1/20 | 0.30 |
| ▸ | NSD2 | O96028 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27142253 | 1.00 | TRPV4 (0.35) | TRPV4KDM4EALDH1A1KMT2ATSHR | |
| SCHEMBL31149230 | 0.85 | TRPV4 (0.36) | TRPV4ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL30681724 | 0.83 | TRPV4 (0.39) | TRPV4 | |
| SCHEMBL27138022 | 0.83 | TRPV4 (0.39) | TRPV4 | |
| SCHEMBL27142166 | 0.82 | TRPV4 (0.42) | TRPV4TSHR | |
| SCHEMBL30039434 | 0.80 | ALDH1A1 (0.44) | TRPV4KDM4EALDH1A1KMT2ATSHR | |
| SCHEMBL2930464 | 0.80 | ALDH1A1 (0.44) | TRPV4KDM4EALDH1A1KMT2ATSHR | |
| SCHEMBL25450390 | 0.78 | TRPV4 (0.38) | TRPV4KMT2A | |
| SCHEMBL31645093 | 0.77 | TRPV4 (0.42) | TRPV4ALDH1A1KMT2ATSHRL3MBTL1 | |
| SCHEMBL27138184 | 0.77 | TRPV4 (0.50) | TRPV4KDM4EALDH1A1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4326719-A1 | PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE | Université de Montréal (CA) | 2024-02-28 | — | — | EP | disclosed |
| EP-4326723-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | Université de Montréal (CA) | 2024-02-28 | — | — | EP | disclosed |
| WO-2022221939-A1 | PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS USES THEREOF FOR TREATING A PROLIFERATIVE DISEASE | UNIVERSITE DE MONTREAL (CA) | 2022-10-27 | — | — | WO | disclosed |
| WO-2022221940-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | UNIVERSITE DE MONTREAL (CA) | 2022-10-27 | — | — | WO | disclosed |