Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 3/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | LCAT | P04180 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21730194 | 1.00 | CTSS (0.46) | CTSSCNR1PIM1CTSKALDH1A1 | |
| SCHEMBL2949577 | 0.98 | CTSS (0.45) | CTSSCNR1PIM1CTSKALDH1A1 | |
| SCHEMBL21730383 | 0.96 | CTSS (0.46) | CTSSCNR1PIM1CTSKALDH1A1 | |
| SCHEMBL23166854 | 0.89 | ALDH1A1 (0.49) | CTSSCNR1CTSKALDH1A1L3MBTL1 | |
| SCHEMBL15347238 | 0.86 | PIM1 (0.53) | PIM1ALDH1A1KDM4ECASP1MAPK1 | |
| SCHEMBL30077085 | 0.86 | PIM1 (0.53) | PIM1ALDH1A1KDM4ECASP1MAPK1 | |
| SCHEMBL27920871 | 0.86 | CTSS (0.44) | CTSSPIM1CTSKALDH1A1L3MBTL1 | |
| SCHEMBL21268766 | 0.84 | ALDH1A1 (0.58) | CTSSPIM1ALDH1A1KDM4EMAPK1 | |
| SCHEMBL30893584 | 0.84 | ALDH1A1 (0.58) | CTSSPIM1ALDH1A1KDM4EMAPK1 | |
| SCHEMBL2814727 | 0.84 | LRRK2 (0.52) | CTSSALDH1A1L3MBTL1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |