Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 2/20 | 0.44 |
| ▸ | HTR3A | P46098 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21730336 | 1.00 | CTSS (0.51) | CTSSJAK2JAK3MAP4K4EGLN2 | |
| SCHEMBL30880817 | 0.92 | CTSS (0.47) | CTSSJAK2JAK3MAP4K4EGLN2 | |
| SCHEMBL21730298 | 0.92 | CTSS (0.47) | CTSSJAK2JAK3MAP4K4EGLN2 | |
| SCHEMBL29907630 | 0.89 | CTSS (0.44) | CTSSJAK2JAK3EGLN2HRH3 | |
| SCHEMBL21730269 | 0.89 | CTSS (0.44) | CTSSJAK2JAK3EGLN2HRH3 | |
| SCHEMBL25236628 | 0.80 | MAP4K4 (0.51) | MAP4K4HRH4HRH3HTR1DHTR3A | |
| SCHEMBL7391451 | 0.79 | CTSS (0.54) | CTSSHRH4HRH3HTR3A | |
| SCHEMBL7393501 | 0.79 | HTR3A (0.57) | MAP4K4HRH4HRH3HTR1DHTR3A | |
| SCHEMBL15014503 | 0.79 | CTSS (0.50) | CTSSHSD11B1HTR3A | |
| SCHEMBL17827960 | 0.77 | HRH3 (0.49) | MAP4K4HRH4HRH3HTR1DHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |