Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | BID | P55957 | 3/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9440243 | 1.00 | CYP11B1 (0.46) | CYP11B1LIPGL3MBTL1NPC1ALDH1A1 | |
| SCHEMBL10982801 | 1.00 | CYP11B1 (0.46) | CYP11B1LIPGL3MBTL1NPC1ALDH1A1 | |
| SCHEMBL27764936 | 0.98 | CYP11B1 (0.47) | CYP11B1LIPGL3MBTL1NPC1ALDH1A1 | |
| SCHEMBL5233261 | 0.93 | CYP11B1 (0.48) | CYP11B1LIPGL3MBTL1NPC1ALDH1A1 | |
| SCHEMBL10982482 | 0.92 | F7 (0.45) | HSD17B10BIDMCL1BCL2L1BAK1 | |
| SCHEMBL10986240 | 0.87 | BID (0.43) | CYP11B1L3MBTL1NPC1ALDH1A1HPGD | |
| SCHEMBL10982811 | 0.86 | FAAH (0.45) | CYP11B1HSD17B10SAE1 | |
| SCHEMBL10988111 | 0.86 | FAAH (0.45) | CYP11B1HSD17B10SAE1 | |
| SCHEMBL29057132 | 0.82 | TDP1 (0.41) | LIPGL3MBTL1TDP1KCNH2BID | |
| SCHEMBL6507690 | 0.82 | TDP1 (0.41) | LIPGL3MBTL1TDP1KCNH2BID |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-A | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |