Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.54 |
| ▸ | CCNC | P24863 | 2/20 | 0.53 |
| ▸ | CDK8 | P49336 | 2/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21033166 | 0.88 | USP30 (0.55) | USP30CCNCCDK8PIK3CGEGLN1 | |
| SCHEMBL30845748 | 0.83 | EGLN1 (0.46) | USP30GRM2PIK3CGTGFBR1EGLN1 | |
| SCHEMBL21033464 | 0.82 | KDM4E (0.55) | USP30PIK3CGEGLN1CLK1 | |
| SCHEMBL30845781 | 0.80 | EGLN1 (0.44) | USP30TGFBR1EGLN1 | |
| SCHEMBL30828852 | 0.80 | GRM2 (0.44) | CCNCCDK8MKNK1MKNK2GRM2 | |
| SCHEMBL30845746 | 0.80 | TGFBR1 (0.49) | TGFBR1EGLN1CLK1 | |
| SCHEMBL30845793 | 0.80 | CCNC (0.48) | CCNCCDK8MKNK1MKNK2GRM2 | |
| SCHEMBL30845768 | 0.80 | TGFBR1 (0.54) | PIK3CGTGFBR1EGLN1 | |
| SCHEMBL30845797 | 0.80 | TGFBR1 (0.48) | TGFBR1EGLN1CLK1 | |
| SCHEMBL30845778 | 0.79 | EGLN1 (0.64) | TGFBR1EGLN1CLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | claimed |
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | disclosed |