Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 11/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21033582 | 0.87 | EGLN1 (0.48) | EGLN1NR4A2DYRK1AHRH4HRH3 | |
| SCHEMBL30828883 | 0.84 | TGFBR1 (0.45) | TGFBR1EGLN1NR4A2DYRK1ACLK1 | |
| SCHEMBL30828878 | 0.83 | TGFBR1 (0.44) | TGFBR1NR4A2DYRK1ACLK1BRD4 | |
| SCHEMBL30845778 | 0.80 | EGLN1 (0.64) | TGFBR1EGLN1DYRK1ACLK1 | |
| SCHEMBL30845786 | 0.80 | EGLN1 (0.63) | TGFBR1EGLN1NR4A2 | |
| SCHEMBL29908155 | 0.80 | USP30 (0.54) | TGFBR1EGLN1CLK1 | |
| SCHEMBL30845746 | 0.78 | TGFBR1 (0.49) | TGFBR1EGLN1NR4A2DYRK1ACLK1 | |
| SCHEMBL30845768 | 0.78 | TGFBR1 (0.54) | TGFBR1EGLN1NR4A2 | |
| SCHEMBL30845779 | 0.77 | TGFBR1 (0.58) | TGFBR1EGLN1 | |
| SCHEMBL8065354 | 0.76 | TGFBR1 (0.50) | TGFBR1EGLN1HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | claimed |
| CN-111542523-B | Heterocyclic compounds as PRMT5 inhibitors | 朱比连特埃皮斯科瑞有限责任公司 | 2024-03-29 | — | — | CN | disclosed |