Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 9/20 | 1.00 |
| ▸ | NPC1 | O15118 | 11/20 | 0.68 |
| ▸ | RAB9A | P51151 | 11/20 | 0.68 |
| ▸ | MEN1 | O00255 | 8/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.68 |
| ▸ | PKM | P14618 | 6/20 | 0.68 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | MLNR | O43193 | 1/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5795075 | 1.00 | STAT3 (1.00) | STAT3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL5797958 | 0.91 | STAT3 (1.00) | STAT3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL29908285 | 0.91 | STAT3 (1.00) | STAT3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL25063001 | 0.89 | STAT3 (0.80) | STAT3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL28574896 | 0.88 | STAT3 (0.78) | STAT3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL25063050 | 0.87 | STAT3 (0.80) | STAT3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL5795728 | 0.83 | NPC1 (0.75) | STAT3NPC1RAB9AMEN1KMT2A | |
| Tizoxanide SCHEMBL375440 | 0.83 | STAT3 (1.00) | STAT3NPC1RAB9AMEN1KMT2A | |
| Tizoxanide SCHEMBL29367981 | 0.83 | STAT3 (1.00) | STAT3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL22680776 | 0.81 | NPC1 (1.00) | STAT3NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456980-A | Application of thiazole compounds in preparation of medicines for treating and preventing cancers | 北京大学 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022206084-A1 | USE OF THIAZOLE COMPOUND IN PREPARATION OF DRUG FOR TREATING AND PREVENTING CANCER | 北京大学 | 2022-10-06 | — | — | WO | disclosed |